Kronbichler Andreas, Kresse Daniela, Yoon Sojung, Lee Keum Hwa, Effenberger Maria, Shin Jae Il
Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.
Department of Internal Medicine, St. Johann County Hospital, St. Johann in Tirol, Austria.
Int J Infect Dis. 2020 Sep;98:180-186. doi: 10.1016/j.ijid.2020.06.052. Epub 2020 Jun 17.
Coronavirus Disease 2019 (COVID-19) is characterized by an unpredictable disease course, ranging from asymptomatic to severe, life-threatening infections. Asymptomatic COVID-19 infections have been described, and the aim of this systematic review was to summarise their presentation forms.
We searched PubMed® and Google® (1 December 2019 to 29 March 2020) and extracted age, laboratory findings, and computed tomography (CT) scans. Pooled incidence rates of clinical characteristics were analyzed using random-effect models.
In total, 506 patients from 34 studies (68 single cases and 438 from case-series) with an asymptomatic course were identified. Patients with normal radiology were younger (19.59 ± 17.17 years) than patients with abnormal radiology (39.14 ± 26.70 years) (p-value = 0.013). Despite being asymptomatic, CT investigations revealed abnormalities in 62.2% of the cases; ground-glass opacities were most frequently observed (43.09% by meta-analysis). Most studies reported normal laboratory findings (61.74% by meta-analysis).
More than half of the patients without any symptoms present with CT abnormalities. Asymptomatic patients may be contagious and thus a potential source of transmission of COVID-19.
2019冠状病毒病（COVID-19）的病程难以预测，从无症状感染到严重的、危及生命的感染都有。无症状COVID-19感染已有报道，本系统评价的目的是总结其表现形式。
我们检索了PubMed®和谷歌®（2019年12月1日至2020年3月29日），并提取了年龄、实验室检查结果和计算机断层扫描（CT）扫描结果。使用随机效应模型分析临床特征的合并发病率。
共纳入34项研究中的506例无症状病程患者（68例单病例和438例病例系列）。影像学正常的患者（19.59±17.17岁）比影像学异常的患者（39.14±26.70岁）年轻（p值=0.013）。尽管无症状，但CT检查显示62.2%的病例存在异常；磨玻璃影最为常见（荟萃分析显示为43.09%）。大多数研究报告实验室检查结果正常（荟萃分析显示为61.74%）。
超过一半的无症状患者存在CT异常。无症状患者可能具有传染性，因此可能是COVID-19的潜在传播源。
