Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Clin Interv Aging. 2020 Jun 3;15:827-839. doi: 10.2147/CIA.S256425. eCollection 2020.
Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.
不同的因素影响着衰老的发展和控制。众所周知，端粒缩短是衰老的分子机制之一。保护帽复合物由六个端粒特异性蛋白组成，这些蛋白参与染色体末端的保护。更具体地说，这个重要的复合物保护端粒免受降解，防止不必要的修复系统的激活，调节端粒酶的活性，并在细胞衰老和与衰老相关的病理中起着关键作用。这篇综述探讨了端粒 DNA 的组织和功能以及端粒在衰老过程中的机制，随后讨论了保护帽成分的关键作用及其在衰老过程中的变化。
