Zhang Nan, Gu Dongmei, Meng Meng, Gordon Marc L
Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, China.
Department of Neurology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China.
Front Aging Neurosci. 2020 Jun 4;12:166. doi: 10.3389/fnagi.2020.00166. eCollection 2020.
Recently, TDP-43 has been recognized as a common proteinopathy in the "oldest old" and a neuropathological comorbidity in patients with Alzheimer's disease (AD). However, since it has a low concentration in cerebrospinal fluid, the presence of TDP-43 in AD is rarely investigated .
Twenty-four patients with amyloid PET confirmed AD and 15 healthy controls (HCs) were included in this study. TDP-43 level in plasma neuronal-derived exosomes (NDEs) was measured by enzyme-linked immunosorbent assay.
TDP-43 level was elevated in patients with AD compared with HCs (median 1.08 ng/ml, IQR 0.72-1.37 ng/ml vs. median 0.66 ng/ml, IQR 0.48-0.76 ng/ml, = 0.002). There was no correlation between TDP-43 level and cognitive function, neuropsychiatric symptoms or APOE genotype in patients with AD.
This study demonstrated increased TDP-43 accumulation in AD patients by examining plasma NDEs, which may provide a window into the effects of TDP-43 on AD progression.
最近，TDP - 43已被认为是“最年长者”中常见的蛋白病，也是阿尔茨海默病（AD）患者的神经病理学合并症。然而，由于其在脑脊液中的浓度较低，AD中TDP - 43的存在情况很少被研究。
本研究纳入了24例经淀粉样蛋白PET确诊的AD患者和15名健康对照（HC）。采用酶联免疫吸附测定法测量血浆神经元衍生外泌体（NDE）中的TDP - 43水平。
与HC相比，AD患者的TDP - 43水平升高（中位数1.08 ng/ml，四分位距0.72 - 1.37 ng/ml，而HC的中位数为0.66 ng/ml，四分位距0.48 - 0.76 ng/ml，P = 0.002）。AD患者的TDP - 43水平与认知功能、神经精神症状或APOE基因型之间无相关性。
本研究通过检测血浆NDE证实AD患者中TDP - 43积累增加，这可能为了解TDP - 43对AD进展的影响提供一个窗口。
