在阿尔茨海默病患者的血浆神经元衍生外泌体中TDP-43水平升高。
TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer's Disease.
作者信息
Zhang Nan, Gu Dongmei, Meng Meng, Gordon Marc L
机构信息
Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, China.
Department of Neurology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China.
出版信息
Front Aging Neurosci. 2020 Jun 4;12:166. doi: 10.3389/fnagi.2020.00166. eCollection 2020.
BACKGROUND
Recently, TDP-43 has been recognized as a common proteinopathy in the "oldest old" and a neuropathological comorbidity in patients with Alzheimer's disease (AD). However, since it has a low concentration in cerebrospinal fluid, the presence of TDP-43 in AD is rarely investigated .
METHODS
Twenty-four patients with amyloid PET confirmed AD and 15 healthy controls (HCs) were included in this study. TDP-43 level in plasma neuronal-derived exosomes (NDEs) was measured by enzyme-linked immunosorbent assay.
RESULTS
TDP-43 level was elevated in patients with AD compared with HCs (median 1.08 ng/ml, IQR 0.72-1.37 ng/ml vs. median 0.66 ng/ml, IQR 0.48-0.76 ng/ml, = 0.002). There was no correlation between TDP-43 level and cognitive function, neuropsychiatric symptoms or APOE genotype in patients with AD.
CONCLUSION
This study demonstrated increased TDP-43 accumulation in AD patients by examining plasma NDEs, which may provide a window into the effects of TDP-43 on AD progression.
背景
最近，TDP - 43已被认为是“最年长者”中常见的蛋白病，也是阿尔茨海默病（AD）患者的神经病理学合并症。然而，由于其在脑脊液中的浓度较低，AD中TDP - 43的存在情况很少被研究。
方法
本研究纳入了24例经淀粉样蛋白PET确诊的AD患者和15名健康对照（HC）。采用酶联免疫吸附测定法测量血浆神经元衍生外泌体（NDE）中的TDP - 43水平。
结果
与HC相比，AD患者的TDP - 43水平升高（中位数1.08 ng/ml，四分位距0.72 - 1.37 ng/ml，而HC的中位数为0.66 ng/ml，四分位距0.48 - 0.76 ng/ml，P = 0.002）。AD患者的TDP - 43水平与认知功能、神经精神症状或APOE基因型之间无相关性。
结论
本研究通过检测血浆NDE证实AD患者中TDP - 43积累增加，这可能为了解TDP - 43对AD进展的影响提供一个窗口。
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