中性粒细胞与淋巴细胞比值作为头颈部鳞状细胞癌总生存和癌症特异性生存的预后指标。
Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck.
作者信息
Ferrandino Rocco M, Roof Scott, Garneau Jonathan, Haidar Yarah, Bates Susan E, Park Yeun-Hee A, Bauml Joshua M, Genden Eric M, Miles Brett, Sigel Keith
机构信息
Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Hospital, New York, New York, USA.
Department of Medicine, Division of Hematology/Oncology, James J. Peters VA Medical Center, Bronx, New York, USA.
出版信息
Head Neck. 2020 Oct;42(10):2830-2840. doi: 10.1002/hed.26329. Epub 2020 Jun 27.
BACKGROUND
Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.
METHODS
We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5-year overall survival and cancer-specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates.
RESULTS
The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all-cause mortality (P < .001) and 44% increased hazard of cancer-specific mortality (P < .001) at 5 years.
CONCLUSIONS
Elevated NLR in HNSCC confers a poor prognosis.
背景
中性粒细胞与淋巴细胞比值（NLR）是一种生物标志物，与实体瘤中的全身炎症和不良预后相关。我们调查了NLR在美国大量头颈癌患者中预测生存的价值。
方法
我们对2000年1月至2017年12月期间诊断为头颈鳞状细胞癌（HNSCC）的退伍军人事务部患者进行了一项回顾性队列研究。我们使用Cox比例风险模型对协变量进行调整，比较了不同NLR三分位数的5年总生存率和癌症特异性生存率。
结果
主要队列由14644名受试者组成，其中99%为男性。与NLR处于较低三分位数的患者相比，NLR处于最高三分位数的患者在5年时全因死亡率风险增加71%（P <.001），癌症特异性死亡率风险增加44%（P <.001）。
结论
HNSCC中NLR升高预示预后不良。
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