Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, 571448, India.
Centre for Research and Development, Unique Biotech Ltd., Plot No. 2, Phase II, Alexandria Knowledge Park, Hyderabad, Telangana, 500078, India.
Probiotics Antimicrob Proteins. 2021 Feb;13(1):12-18. doi: 10.1007/s12602-020-09681-4.
In this placebo-controlled, double-blind clinical trial, we have investigated the effect of multi-strain probiotic (Bacillus coagulans Unique IS2, Lactobacillus rhamnosus UBLR58, Bifidobacterium lactis UBBLa70, Lactobacillus plantarum UBLP40 (each of 2 billion CFU); Bifidobacterium breve UBBr01, Bifidobacterium infantis UBBI01 (each of 1 billion CFU)) capsule with glutamine (250 mg) on students facing examination stress. A total of 80 students (18-24 years) were enrolled and randomised to receive multi-strain probiotic or placebo capsules twice a day for 28 days (i.e. pre- and during examination). The stress was analysed at the baseline and the end of the treatment by using the perceived stress scale (PSS), depression anxiety stress scale (DASS), and state-trait anxiety inventory (STAI) questionnaire. The serum cortisol levels were also determined. As a result, at the end of the trial, a total of 74 students completed the study, and those who consumed probiotic capsules showed a significant reduction in PSS, DASS, and STAI scores, and serum cortisol levels from the baseline as compared with placebo. No adverse events were reported during the study. In conclusion, the multi-strain probiotic is effective in reducing stress associated with examination. CTRI/2019/03/018178.
在这项安慰剂对照、双盲临床试验中，我们研究了多菌株益生菌（凝结芽孢杆菌 Unique IS2、鼠李糖乳杆菌 UBLR58、双歧杆菌 lactis UBBLa70、植物乳杆菌 UBLP40（每种 20 亿 CFU）；短双歧杆菌 UBBr01、婴儿双歧杆菌 UBBI01（每种 10 亿 CFU））胶囊联合谷氨酰胺（250mg）对面临考试压力的学生的影响。共招募了 80 名（18-24 岁）学生，并随机分为两组，每天服用两次多菌株益生菌或安慰剂胶囊，共 28 天（即考试前和考试期间）。使用感知压力量表（PSS）、抑郁焦虑压力量表（DASS）和状态特质焦虑量表（STAI）问卷在基线和治疗结束时分析压力。还测定了血清皮质醇水平。结果，试验结束时，共有 74 名学生完成了研究，与安慰剂组相比，服用益生菌胶囊的学生 PSS、DASS 和 STAI 评分以及血清皮质醇水平从基线开始显著降低。研究期间未报告不良反应。总之，多菌株益生菌可有效减轻与考试相关的压力。CTRI/2019/03/018178。
