Center for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, Italy.
Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong SAR, P. R. China.
Adv Mater. 2020 Aug;32(33):e2002129. doi: 10.1002/adma.202002129. Epub 2020 Jun 29.
Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.
细菌、病毒和真菌引起的皮肤感染很难通过传统的局部给药来治疗，因为药物很难穿透角质层。这导致药物到达感染部位的生物利用度低，并且缺乏长效释放。新兴的抗菌经皮和眼部微针贴片已成为用于递各种抗菌、抗真菌和抗病毒疗法的有前途的医疗设备。在本综述中，讨论了皮肤解剖结构及其屏障以及皮肤感染。概述了设计抗菌微针的潜在策略及其靶向治疗。最后，讨论了与个性化药物治疗和针对特定微生物物种的选择性毒性相关的生物传感微针贴片。
