1University of California Davis, Sacramento, California.
2Oregon Health & Science University, Portland, Oregon.
Am J Trop Med Hyg. 2020 Sep;103(3):1125-1128. doi: 10.4269/ajtmh.20-0196.
Subarachnoid neurocysticercosis (SANCC) is a severe and progressive brain infection with . We performed a pilot study of noninvasive screening for SANCC in two endemic villages in northern Peru using a urine antigen screen followed by brain magnetic resonance imaging for participants with elevated levels of antigen. Among the 978 participants screened, we identified eight individuals with SANCC, many of whom were asymptomatic. This represents a minimum prevalence of 0.8% of SANCC, a level higher than expected based on prior studies, and a positive predictive value of 62% for our novel urine screening test. Future studies should confirm whether early detection and management improve clinical outcomes.
脑囊虫病（SANCC）是一种严重且逐渐恶化的脑部感染病。我们在秘鲁北部的两个流行地区进行了一项使用尿液抗原检测进行非侵入性 SANCC 筛查的初步研究，对于抗原水平升高的参与者，再进行脑部磁共振成像。在接受筛查的 978 名参与者中，我们发现了 8 名患有 SANCC 的个体，其中许多人无症状。这代表 SANCC 的最低患病率为 0.8%，高于先前研究的预期水平，我们新的尿液筛查检测的阳性预测值为 62%。未来的研究应该确认早期检测和管理是否能改善临床结果。
