Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
Cardiovasc Hematol Disord Drug Targets. 2020;20(4):297-304. doi: 10.2174/1871529X20666200630112610.
The study aimed to investigate the antihyperglycemic activity of Matricaria pubescens.
Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco.
The present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).
The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay.
The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro antioxidant activity of AEAPMP has been shown.
In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.
本研究旨在探究春黄菊的降血糖活性。
春黄菊（Def）。舒尔茨（菊科）在摩洛哥传统上常用于治疗糖尿病。
本研究旨在评估春黄菊地上部分水提物（M. pubescens）的降血糖和抗氧化作用。
研究考察了单次和重复口服 40mg/kg 剂量的春黄菊地上部分水提物（AEAPMP）对正常和链脲佐菌素诱导的糖尿病大鼠血糖的影响。此外，根据苏木精-伊红法进行了胰腺和肝脏的组织病理学检查。采用 DPPH 法测定抗氧化活性。
结果表明，M. pubescens 的水提物（AEAPMP）对 STZ 诱导的糖尿病大鼠的血糖水平有显著的降低作用。此外，AEAPMP 改善了肝和胰腺的组织病理学。此外，还显示了 AEAPMP 的体外抗氧化活性。
总之，本研究表明春黄菊具有防治糖尿病相关高血糖的有益作用。
