Norioka K, Hara M, Harigai M, Kitani A, Hirose T, Suzuki K, Kawakami M, Tabata H, Kawagoe M, Nakamura H
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Biochem Biophys Res Commun. 1988 Jun 30;153(3):1045-50. doi: 10.1016/s0006-291x(88)81334-2.
The effect of culture supernatants of endothelial cell (EC) lines on the immunoglobulin-M(IgM) synthesis by human B cell line, SKW6-CL4 cells, was investigated. Supernatants of human EC stimulated IgM synthesis, as high as 6-fold, but supernatants of bovine EC did not. This enhancing activity was completely blocked by addition of anti-human B cell stimulatory factor-2/interleukin-6 (BSF-2/IL-6) antibody. These data suggest that human EC might participate in the human antibody production system by producing soluble factor, BSF-2/IL-6.
研究了内皮细胞（EC）系的培养上清液对人B细胞系SKW6-CL4细胞免疫球蛋白M（IgM）合成的影响。人EC的上清液刺激IgM合成，刺激倍数高达6倍，但牛EC的上清液则无此作用。添加抗人B细胞刺激因子-2/白细胞介素-6（BSF-2/IL-6）抗体可完全阻断这种增强活性。这些数据表明，人EC可能通过产生可溶性因子BSF-2/IL-6参与人体抗体产生系统。
