青少年大脑认知发展研究中 9-10 岁儿童的产前大麻暴露与睡眠结果。
Prenatal cannabis exposure and sleep outcomes in children 9-10 years of age in the adolescent brain cognitive development study.
机构信息
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder. Muenzinger Psychology Building, Boulder, CO, USA.
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder. Muenzinger Psychology Building, Boulder, CO, USA.
出版信息
Sleep Health. 2020 Dec;6(6):787-789. doi: 10.1016/j.sleh.2020.05.006. Epub 2020 Jun 28.
OBJECTIVES
Analyze the associations between prenatal cannabis exposure and child sleep outcomes.
METHODS
Data from the Adolescent Brain Cognitive Development Study (ABCD Study®) was used to determine whether maternal reports of prenatal cannabis use were associated with child sleep outcomes among 11,875 children ages 9-10 controlling for covariates including prenatal substance exposure, mother's education, combined household income, parental marital status, race, child sex, and child age.
RESULTS
Endorsement of any prenatal cannabis use was associated with symptoms of disorders of initiating and maintaining sleep, disorders of arousal, sleep wake disorders, disorders of excessive somnolence, and a summed sleep disorder score (all β > 0.10 and p < 0.03) while frequency of prenatal daily cannabis use was significantly associated with disorders of excessive somnolence (β = 0.29, p = 0.03).
CONCLUSIONS
Although causality is not established, the results suggest potential long-term effects of prenatal cannabis exposure on sleep and the prudence of abstinence from cannabis use while pregnant.
目的
分析产前大麻暴露与儿童睡眠结果之间的关联。
方法
使用青少年大脑认知发展研究（ABCD 研究®）的数据，确定在控制了产前物质暴露、母亲的教育程度、家庭总收入、父母婚姻状况、种族、儿童性别和年龄等协变量的情况下，母亲报告的产前大麻使用是否与 11875 名 9-10 岁儿童的睡眠结果有关。
结果
任何产前大麻使用的认可都与入睡和维持睡眠障碍、觉醒障碍、睡眠-觉醒障碍、过度嗜睡障碍以及总和睡眠障碍评分相关（所有β>0.10，p<0.03），而产前每日大麻使用的频率与过度嗜睡障碍显著相关（β=0.29，p=0.03）。
结论
尽管因果关系尚未确定，但结果表明产前大麻暴露对睡眠可能存在长期影响，孕妇应谨慎避免使用大麻。
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