Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX.
Gastrointest Endosc. 2012 Feb;75(2):411-5, 415.e1. doi: 10.1016/j.gie.2011.09.052.
Gastric electric stimulation (GES) at a high-frequency, low-energy setting is an option for treating refractory gastroparesis. The currently available commercial stimulator, the Enterra neurostimulator (Medtronic Inc, Minneapolis, MN), however, requires surgical implantation and is powered by a nonrechargeable battery.
To develop and test a miniature wireless GES device for endoscopic implantation in an experimental model.
In-vivo gastric signals were recorded and measured in a nonsurvival swine model (n = 2; 110-lb animals).
An endoscopically placed, wireless GES device was inserted into the stomach through an overtube; the two GES electrodes were endoscopically attached to the gastric mucosa and secured with endoclips to permit stimulation.
Stable electrogastrogram measures were observed during GES stimulation.
Electrogastrogram recordings demonstrated that gastric slow waves became more regular and of constant amplitudes when stomach tissues were stimulated, in comparison with no stimulation. The frequency-to-amplitude ratio also changed significantly with stimulation.
Nonsurvival pig studies.
Gastric electric stimulation is feasible by our endoscopically implanted, wireless GES device.
采用高频、低能量设置的胃电刺激（GES）是治疗难治性胃轻瘫的一种选择。然而，目前可用的商业刺激器——Enterra 神经刺激器（美敦力公司，明尼苏达州明尼阿波利斯）需要手术植入，并由不可充电电池供电。
开发和测试一种用于内镜植入的微型无线 GES 设备，用于实验模型。
在非生存猪模型（n = 2；110 磅动物）中记录和测量胃内信号。
通过外套管将一个可内镜放置的无线 GES 设备插入胃中；将两个 GES 电极通过内镜附于胃黏膜上，并使用内镜夹固定以进行刺激。
观察 GES 刺激期间稳定的胃电图测量值。
与无刺激相比，胃电记录显示当胃组织受到刺激时，胃慢波变得更加规则且幅度恒定。频率-幅度比也随刺激显著变化。
非生存猪研究。
我们的内镜植入式无线 GES 设备可实现胃电刺激。
