Biochemistry and Molecular Biology Department, Research Division, Dasman Diabetes Institute, P.O. Box1180, 15462, Dasman, Kuwait.
Research Division, Dasman Diabetes Institute, Dasman, Kuwait.
Sci Rep. 2020 Jun 30;10(1):10635. doi: 10.1038/s41598-020-67624-z.
Spexin is a novel neuropeptide playing an emerging role in metabolic diseases such as obesity and diabetes via involvement in energy homeostasis and food intake. The present study investigated the effects of obesity and type 2 diabetes (T2D) on circulating levels of spexin and its modulation by physical exercise. Normal-weight (n = 50) and obese adults with and without T2D (n = 69 and n = 66, respectively) were enrolled in the study. A subgroup of obese participants (n = 47) underwent a supervised 3-month exercise programme. Plasma spexin levels were measured by ELISA and correlated with various markers. Plasma spexin levels decreased in obese participants with or without T2D compared with those of normal-weight participants (0.43 ± 0.11, 0.44 ± 0.12 and 0.61 ± 0.23 ng/ml, respectively; P < 0.001). Spexin levels negatively correlated with adiposity markers and blood pressure in the whole study population (P < 0.05). Multiple regression analysis revealed blood pressure was the greatest predictive determinant of plasma spexin levels, which significantly increased in response to physical exercise in obese participants without and with T2D (P < 0.05). Spexin levels significantly increased only in responders to exercise (those with increased oxygen consumption, VO max) with a concomitant improvement in metabolic profile. In conclusion, plasma spexin levels may be an indicator of response to physical exercise.
Spexin 是一种新型神经肽，通过参与能量平衡和摄食来在肥胖和糖尿病等代谢疾病中发挥作用。本研究调查了肥胖和 2 型糖尿病（T2D）对循环 spexin 水平的影响及其对运动的调节作用。纳入了正常体重（n = 50）和肥胖伴或不伴 T2D 的成年人（n = 69 和 n = 66）。肥胖组的一部分参与者（n = 47）接受了为期 3 个月的监督运动计划。通过 ELISA 测量血浆 spexin 水平，并与各种标志物相关联。与正常体重组相比，肥胖伴或不伴 T2D 的参与者血浆 spexin 水平降低（0.43 ± 0.11、0.44 ± 0.12 和 0.61 ± 0.23 ng/ml；P < 0.001）。Spexin 水平与整个研究人群中的肥胖标志物和血压呈负相关（P < 0.05）。多元回归分析显示，血压是血浆 spexin 水平的最大预测决定因素，在肥胖伴或不伴 T2D 的参与者中，运动可显著增加血浆 spexin 水平（P < 0.05）。Spexin 水平仅在运动应答者（那些增加了耗氧量，VO max）中显著增加，同时代谢谱得到改善。总之，血浆 spexin 水平可能是对运动反应的指标。
