Nabati Maryam, Namazi Seyed Shojaeddin, Yazdani Jamshid, Sharif Nia Hamid
Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Gen Med. 2020 Jun 11;13:297-303. doi: 10.2147/IJGM.S253357. eCollection 2020.
Systolic and diastolic blood pressure is associated with physiologic changes of aortic wall and left ventricular structure. We aimed to evaluate aortic stiffness index and distensibility, global longitudinal strain (GLS), post systolic index (PSI) in hypertensive patients and compare these parameters with normotensive subjects.
Eighty-two patients (42 hypertensive compared with 40 normotensive subjects) with preserved left ventricular ejection fraction and without significant coronary artery disease were enrolled in the study. Systolic and diastolic blood pressure was measured by automated BP measurement system. Aortic stiffness index and distensibility, GLS and PSI were measured by transthoracic echocardiography and compared in both study groups.
Aortic stiffness index (0.097 vs 0.069) and E/e´ (8.16 vs 6.56) were significantly higher in hypertensive patients, respectively (<0.05). Aortic distensibility (cm/dyn) (0.28 vs 0.42) and e´ (cm/s) (8.25 vs 9.52) were significantly lower in hypertensive patients than normotensive subjects (<0.05). PSI and GLS were not significantly different between both study groups. Aortic stiffness index and distensibility had significant correlation with age in normotensive subjects while this correlation was not statistically significant in hypertensive patients.
Hypertension is associated with diastolic dysfunction and abnormal aortic wall compliance. Age-related aortic wall changes can present early in hypertensive patients.
收缩压和舒张压与主动脉壁及左心室结构的生理变化相关。我们旨在评估高血压患者的主动脉僵硬度指数和扩张性、整体纵向应变（GLS）、收缩后指数（PSI），并将这些参数与血压正常的受试者进行比较。
本研究纳入了82例左心室射血分数保留且无显著冠状动脉疾病的患者（42例高血压患者与40例血压正常的受试者）。通过自动血压测量系统测量收缩压和舒张压。通过经胸超声心动图测量主动脉僵硬度指数和扩张性、GLS和PSI，并在两个研究组中进行比较。
高血压患者的主动脉僵硬度指数（0.097对0.069）和E/e´（8.16对6.56）分别显著更高（<0.05）。高血压患者的主动脉扩张性（cm/dyn）（0.28对0.42）和e´（cm/s）（8.25对9.52）显著低于血压正常的受试者（<0.05）。两个研究组之间的PSI和GLS无显著差异。在血压正常的受试者中，主动脉僵硬度指数和扩张性与年龄有显著相关性，而在高血压患者中这种相关性无统计学意义。
高血压与舒张功能障碍及主动脉壁顺应性异常相关。与年龄相关的主动脉壁变化在高血压患者中可能较早出现。
