Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California Berkeley, Berkeley, CA 94720, USA.
Dev Cell. 2020 Jul 20;54(2):226-238. doi: 10.1016/j.devcel.2020.06.010. Epub 2020 Jun 30.
The lysosome is an essential catabolic organelle that consumes cellular biomass to regenerate basic building blocks that can fuel anabolic reactions. This simple view has evolved more recently to integrate novel functions of the lysosome as a key signaling center, which can steer the metabolic trajectory of cells in response to changes in nutrients, growth factors, and stress. Master protein kinases and transcription factors mediate the growth-promoting and catabolic activities of the lysosome and undergo a complex interplay that enables cellular adaptation to ever-changing metabolic conditions. Understanding how this coordination occurs will shed light on the fundamental logic of how the lysosome functions to control growth in the context of development, tissue homeostasis, and cancer.
溶酶体是一种重要的分解代谢细胞器，它消耗细胞生物质来再生基本构建块，为合成反应提供燃料。最近，这种简单的观点已经发展为将溶酶体作为一个关键信号中心的新功能整合在一起，这个信号中心可以根据营养物质、生长因子和应激的变化来引导细胞的代谢轨迹。主要的蛋白激酶和转录因子介导溶酶体的促生长和分解代谢活性，并经历复杂的相互作用，使细胞能够适应不断变化的代谢条件。了解这种协调是如何发生的，将揭示溶酶体在发育、组织稳态和癌症等背景下控制生长的基本逻辑。
