Nelson Gill, Ndlovu Ntombizodwa, Christofides Nicola, Hlungwani Tintswalo M, Faust Irene, Racette Brad A
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South Africa.
UCL Institute for Global Health, Research Department of Infection & Population Health, University College London, London, UK.
Parkinsons Dis. 2020 Jun 13;2020:7542138. doi: 10.1155/2020/7542138. eCollection 2020.
There are very few epidemiological studies investigating Parkinson's disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use.
The objective of the study was to validate two commonly used PD questionnaires in an African population.
The PD Screening Questionnaire (PDSQ) and Parkinson's Disease Questionnaire (PDQ-39) were modified and translated into Afrikaans, Setswana, and isiZulu and administered to a sample of healthy local residents. We assessed the internal consistencies and cluster characteristics of the questionnaires, using a Cronbach's alpha test and exploratory factor analysis. The questionnaires were then administered to a population-based sample of 416 research participants. We evaluated the correlations between the questionnaires and both a timed motor task and the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3), using locally weighted scatterplot smoothing (LOWESS) regression analysis and Spearman's rank correlation.
Both questionnaires had high overall internal consistency (Cronbach's alpha = 0.86 and 0.95, respectively). The modified PDQ-39 had evidence of five subscales, with Factor 1 explaining 57% and Factor 2 explaining 14%, of the variance in responses. The PDSQ and PDQ-39 scores were correlated with the UPDRS3 score ( = 0.35, < 0.001; and = 0.28, < 0.001, respectively).
The translated PDSQ and PDQ-39 questionnaires demonstrated high internal consistency and correlations with clinical severity of parkinsonism and a timed motor task, suggesting that they are valid tools for field-based epidemiological studies.
在非洲，针对帕金森病（PD）的流行病学研究非常少。非洲有数百种地方语言和方言，这使得传统的筛查和临床评估工具难以使用。
本研究的目的是在非洲人群中验证两种常用的帕金森病问卷。
对帕金森病筛查问卷（PDSQ）和帕金森病问卷（PDQ-39）进行修改，并翻译成南非荷兰语、塞茨瓦纳语和祖鲁语，然后施用于当地健康居民样本。我们使用克朗巴哈系数检验和探索性因子分析评估问卷的内部一致性和聚类特征。然后将问卷施用于416名基于人群的研究参与者样本。我们使用局部加权散点图平滑（LOWESS）回归分析和斯皮尔曼等级相关性评估问卷与定时运动任务以及统一帕金森病评定量表运动部分3（UPDRS3）之间的相关性。
两份问卷总体内部一致性都很高（克朗巴哈系数分别为0.86和0.95）。修改后的PDQ-39有五个子量表的证据，其中因子1解释了反应方差的57%，因子2解释了14%。PDSQ和PDQ-39得分与UPDRS3得分相关（分别为r = 0.35，P < 0.001；r = 0.28，P < 0.001）。
翻译后的PDSQ和PDQ-39问卷显示出较高的内部一致性，并且与帕金森病的临床严重程度和定时运动任务相关，表明它们是基于现场的流行病学研究的有效工具。
