University of Florida Health, Gainesville, FL.
University of Florida Health, Gainesville, FL.
Chest. 2020 Dec;158(6):e267-e268. doi: 10.1016/j.chest.2020.06.049. Epub 2020 Jul 3.
Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.
全身性毛细血管渗漏综合征是一种罕见的疾病，其特征为功能失调的炎症反应、内皮功能障碍以及液体从血管空间渗漏到间质空间，导致休克、血液浓缩、低白蛋白血症，并随后发生器官衰竭。这种情况可能是特发性的，也可能继发于潜在的病因，包括病毒感染。在这里，我们描述了一例急性 2019 冠状病毒病（COVID-19）感染患者，其表现为血液浓缩、休克和低白蛋白血症。随后，该患者发生横纹肌溶解症和四肢所有间隔室综合征，需要进行筋膜切开术。这是首例与 COVID-19 感染相关的全身性毛细血管渗漏综合征的报告病例。该病例增加了与这种病毒感染相关的不断发展的炎症效应谱。
