系统性红斑狼疮中抗组蛋白自身抗体同种型谱的个体差异。
Individual variation in the isotype profile of anti-histone autoantibodies in systemic lupus erythematosus.
作者信息
Fellows G, Gittoes N, Scott D G, Coppock J S, Wainwright A, Goodall M, Turner B M
机构信息
Department of Anatomy, University of Birmingham Medical School, UK.
出版信息
Clin Exp Immunol. 1988 Jun;72(3):440-5.
Using a solid-phase radioimmunoassay we have measured levels of anti-histone autoantibodies of the IgG, IgA and IgM heavy chain classes in 40 patients with systemic lupus erythematosus. Twenty-two patients (55%) had significantly elevated levels of at least one anti-histone isotype. Our results reveal four characteristics of the anti-histone response. (1) There is wide variation between patients in the isotype profile of anti-histone antibodies and these isotype profiles are a consistent individual characteristic. (2) There is no significant correlation between the level of IgG, IgA and IgM anti-histone in individual patients and a marked tendency for a single isotype (either IgG, IgA or IgM) to predominate in any one patient. (3) IgG anti-histone antibodies are predominantly of the IgG1 subclass. (4) Among 12 patients tested, IgG and IgA antibodies showed a preference for histones 1 and 2B whereas IgM antibodies showed no consistent preference for individual histones.
我们采用固相放射免疫分析法，检测了40例系统性红斑狼疮患者IgG、IgA和IgM重链类别的抗组蛋白自身抗体水平。22例患者（55%）至少有一种抗组蛋白同种型水平显著升高。我们的结果揭示了抗组蛋白反应的四个特征。（1）患者之间抗组蛋白抗体的同种型谱差异很大，这些同种型谱是个体的一个一致特征。（2）个体患者中IgG、IgA和IgM抗组蛋白水平之间无显著相关性，且在任何一名患者中单一同种型（IgG、IgA或IgM）占主导的趋势明显。（3）IgG抗组蛋白抗体主要为IgG1亚类。（4）在接受检测的12例患者中，IgG和IgA抗体对组蛋白1和2B表现出偏好，而IgM抗体对单个组蛋白没有一致的偏好。
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