Segarra Sergi, Sanmiguel David, Zuriaga Eliseo, Leclerc Sophie, Cabañas Jesús, Seigneuric Estelle, Miquel Aurélie, Vázquez Ana, Ferrer Lluís
R&D Bioiberica S.A.U., Avinguda dels Països Catalans, 34, 08950 Esplugues de Llobregat, Spain.
Clínica Veterinaria Wecan De Carreres, Avinguda Mutxamel, 1, Local 2, 03550 Sant Joan d'Alacant, Spain.
Vet Sci. 2023 Jun 7;10(6):389. doi: 10.3390/vetsci10060389.
The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently available options are not always totally effective and might have some associated adverse effects, novel alternatives are needed. For this reason, a new collar for CAD was developed with 2.5% of a sphingomyelin-rich lipid extract (LE) with proven benefits for skin health. The release of the active ingredient when incorporated into the collar was tested in vitro, showing an adequate kinetic profile. Then, the efficacy and safety of the collar were assessed in 12 client-owned dogs with CAD in a pilot study. After eight weeks, the dogs experienced significant clinical improvements on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, Pruritus Index for Canine Atopic Dermatitis (PCAD) and Pruritus Visual Analogue Scale (PVAS) scores, without any adverse effects. Additionally, further in vitro studies were performed, indicating that this LE collar should be compatible with antiparasitic collars (with deltamethrin or imidacloprid/flumethrin) if worn simultaneously. Given the observed benefits of this LE collar, combining it with other CAD therapies could potentially allow for drug sparing, reduction in adverse effects, enhanced owner compliance, and reduced treatment costs.
犬特应性皮炎（CAD）的管理很复杂，需要采取多模式治疗，结合局部和全身治疗。鉴于目前可用的治疗方法并不总是完全有效，而且可能有一些相关的不良反应，因此需要新的替代方法。出于这个原因，研发了一种用于CAD的新型项圈，其中含有2.5%富含鞘磷脂的脂质提取物（LE），已证实对皮肤健康有益。将活性成分掺入项圈后，在体外测试了其释放情况，显示出合适的动力学特征。然后，在一项初步研究中，对12只患CAD的宠物犬主人的犬只评估了项圈的疗效和安全性。八周后，这些犬只在犬特应性皮炎范围和严重程度指数（CADESI）-4、犬特应性皮炎瘙痒指数（PCAD）和瘙痒视觉模拟量表（PVAS）评分上有显著的临床改善，且无任何不良反应。此外，还进行了进一步的体外研究，表明如果同时佩戴，这种LE项圈应与抗寄生虫项圈（含溴氰菊酯或吡虫啉/氟氯氰菊酯）兼容。鉴于这种LE项圈所观察到的益处，将其与其他CAD治疗方法相结合可能会实现药物节省、减少不良反应、提高主人依从性并降低治疗成本。
