Department of Biological Function of Foods, Institute of Animal Reproduction and Food Research, Division of Food Science, Tuwima 10, 10-748 Olsztyn, Poland.
Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research, Division of Food Science, Tuwima 10, 10-748 Olsztyn, Poland.
Molecules. 2020 Jun 25;25(12):2921. doi: 10.3390/molecules25122921.
The objective of this study was to compare the effects of the dietary inclusion of hemp seed oil (HO) and poppy seed oil (PO) on the lipid metabolism and antioxidant status of lean and genetically obese Zucker rats. The rats were fed a control diet for laboratory rodents or a modification with HO or PO. Both oils reduced body and epididymal fat and liver cholesterol levels and promoted oxidative stress in the liver of obese rats. The HO reduced plasma triglycerides and had a stronger liver cholesterol-lowering effect in obese rats than PO. In the lean rats, HO and PO had no effects on the body fat content, plasma lipid profile, or lipid metabolism in the liver. HO considerably elevated the content of α-linolenic acid in the liver and increased the liver ratio of reduced glutathione (GSH)/oxidized glutathione (GSSG) in the lean rats. In conclusion, the regular consumption of both oils increases the accumulation of essential fatty acids in the liver of healthy animals, whilst not having any adverse effects on the body, whereas in genetically obese rats, the effects of both dietary oils on the lipid metabolism and antioxidant status are unequivocal and only partially beneficial.
本研究旨在比较大麻籽油（HO）和罂粟籽油（PO）对瘦型和遗传性肥胖 Zucker 大鼠脂代谢和抗氧化状态的影响。大鼠分别喂食实验室啮齿动物对照饲料或添加 HO 或 PO 的改良饲料。两种油均可降低瘦型和肥胖型大鼠的体脂和附睾脂肪及肝脏胆固醇水平，并促进肥胖型大鼠肝脏的氧化应激。HO 降低了肥胖型大鼠的血浆甘油三酯水平，且对肥胖型大鼠肝脏胆固醇的降低作用强于 PO。在瘦型大鼠中，HO 和 PO 对体脂含量、血浆脂质谱或肝脏脂代谢均无影响。HO 显著增加了肝脏中 α-亚麻酸的含量，并增加了瘦型大鼠肝脏中还原型谷胱甘肽（GSH）/氧化型谷胱甘肽（GSSG）的比值。总之，两种油的常规摄入均可增加健康动物肝脏中必需脂肪酸的积累，而对机体无不良影响，而在遗传性肥胖型大鼠中，两种膳食油对脂代谢和抗氧化状态的影响是明确的，且仅部分有益。
