Department of Animal Nutrition and Feed Science, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5 Str., 10-719, Olsztyn, Poland.
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Str., 10-748, Olsztyn, Poland.
Sci Rep. 2021 Oct 22;11(1):20895. doi: 10.1038/s41598-021-00397-1.
We hypothesized that milk thistle seed or seed oil dietary supplementation reduces intestinal, liver and lipid disorders specific to genetic obesity, and the seeds can be more efficient in doing so. Lean and obese male Zucker rats were allocated to 4 groups: the lean (LC) and obese control (OC) groups fed a standard diet and the other 2 obese groups fed a diet supplemented with milk thistle seed oil (O + MTO) or milk thistle seeds (O + MTS). After 5 weeks of feeding, the cecal SCFA pool was slightly and significantly lower in OC and O + MTO compared with LC and O + MTS. The liver fat content was greater in OC, O + MTO and O + MTS compared with LC; however, it was significantly lower in O + MTS than in OC and O + MTO. The plasma cholesterol was greater in OC compared with LC, O + MTO and O + MTS; however, it was significantly greater in O + MTO and O + MTS compared with LC. The plasma bilirubin was detected in OC and O + MTO, whereas it was not present in LC and O + MTS. Milk thistle seeds can improve fermentation events in the distal intestine and reduce other disorders specific to genetically obese rats, and the seed PUFAs are responsible for that to a lesser extent.
我们假设奶蓟草种子或种子油的饮食补充可以减少与遗传肥胖相关的肠道、肝脏和脂质紊乱，而且种子可能更有效。瘦型和肥胖型雄性 Zucker 大鼠被分配到 4 组：瘦型（LC）和肥胖对照组（OC）喂食标准饮食，另外 2 组肥胖大鼠喂食补充奶蓟草种子油（O+MTO）或奶蓟草种子（O+MTS）的饮食。喂养 5 周后，OC 和 O+MTO 组的盲肠短链脂肪酸池明显低于 LC 和 O+MTS 组。OC、O+MTO 和 O+MTS 组的肝脂肪含量高于 LC 组；然而，O+MTS 组的肝脂肪含量明显低于 OC 和 O+MTO 组。OC 组的血浆胆固醇含量高于 LC、O+MTO 和 O+MTS 组；然而，O+MTO 和 O+MTS 组的血浆胆固醇含量明显高于 LC 组。OC 和 O+MTO 组检测到血浆胆红素，而 LC 和 O+MTS 组则没有。奶蓟草种子可以改善远端肠道的发酵事件，减少与遗传肥胖大鼠相关的其他紊乱，而种子多不饱和脂肪酸的作用则较小。
