Hashimoto M, Bando T, Iriki M, Hashimoto K
Department of Physiology, Yamanashi Medical College, Japan.
Am J Physiol. 1988 Oct;255(4 Pt 2):R527-33. doi: 10.1152/ajpregu.1988.255.4.R527.
Effects of indomethacin, a potent inhibitor of prostaglandin (PG) synthesis, on the fever induced by recombinant human interleukin 1-alpha (rhIL 1-alpha) was studied in conscious rabbits. Intracerebroventricularly administered rhIL 1-alpha induced a dose-dependent increase in colonic temperature that was prominently suppressed by pretreatment with indomethacin given either intracerebroventricularly or subcutaneously. On the other hand, fever induced by intravenous administration of rhIL 1-alpha was not completely suppressed by either subcutaneous or intracerebroventricular indomethacin; a small rise in colonic temperature persisted at approximately 45 min after rhIL 1-alpha injection. This rise in colonic temperature was suppressed when indomethacin was given both intracerebroventricularly and subcutaneously. It is suggested that PGs synthesized in the central nervous system contribute to the IL 1 fever and that part of IL 1-alpha given peripherally is also transmitted into the central nervous system to contribute to IL 1 fever.
在清醒的家兔身上研究了强效前列腺素（PG）合成抑制剂吲哚美辛对重组人白细胞介素1-α（rhIL 1-α）诱导发热的影响。脑室内注射rhIL 1-α可引起结肠温度剂量依赖性升高，预先经脑室内或皮下给予吲哚美辛可显著抑制该升高。另一方面，静脉注射rhIL 1-α引起的发热，无论是皮下还是脑室内给予吲哚美辛都不能完全抑制；rhIL 1-α注射后约45分钟结肠温度仍有小幅升高。当脑室内和皮下同时给予吲哚美辛时，这种结肠温度升高受到抑制。提示在中枢神经系统合成的PGs参与IL 1介导的发热，并且外周给予的部分IL 1-α也传入中枢神经系统参与IL 1介导的发热。
