Molecular Cell Biology Laboratory, Department of Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan.
Mitsubishi-Chemical Foods Corporation, Marunouchi 1-1-1, Chiyoda-ku, Tokyo 100-8251, Japan.
Int J Mol Sci. 2020 Jun 25;21(12):4533. doi: 10.3390/ijms21124533.
Obesity induces serious diseases such as diabetes and cardiovascular disease. It has been reported that obesity increases the risk of cognitive dysfunction. Cognitive dysfunction is a characteristic symptom of Alzheimer's and Parkinson's diseases. However, the detailed mechanisms of obesity-induced cognitive dysfunction have not yet been elucidated. The onset and progression of obesity-induced severe secondary diseases such as diabetes, cardiovascular events, and hypertension are deeply connected to oxidative stress. We hypothesized that obesity induces cognitive dysfunction via acceleration of reactive oxygen species (ROS) production. Vitamin E, which is a lipophilic vitamin, has strong antioxidative effects and consists of two groups: tocopherols and tocotrienols. Recently, it has been demonstrated that tocotrienols have strong neuroprotective and anti-obesity effects. In this study, we fed mice a high-fat diet (HFD) from 9 to 14 months of age and assessed the effect of tocotrienols treatment on body weight, brain oxidation levels, and cognitive function. The results revealed that treatment with tocotrienols inhibited body weight gain; further, tocotrienols reached the brain and attenuated oxidation in HFD-treated mice. These results indicate that tocotrienols have anti-obesity effects and inhibit obesity-induced brain oxidation.
肥胖会引发糖尿病和心血管疾病等严重疾病。据报道，肥胖会增加认知功能障碍的风险。认知功能障碍是阿尔茨海默病和帕金森病的特征性症状。然而，肥胖引起的认知功能障碍的详细机制尚未阐明。肥胖引起的严重继发性疾病，如糖尿病、心血管事件和高血压的发病和进展与氧化应激密切相关。我们假设肥胖通过加速活性氧（ROS）的产生引起认知功能障碍。维生素 E 是一种脂溶性维生素，具有很强的抗氧化作用，它由两组组成：生育酚和三烯生育酚。最近的研究表明，三烯生育酚具有很强的神经保护和抗肥胖作用。在这项研究中，我们让老鼠从 9 到 14 个月大时食用高脂肪饮食（HFD），并评估了三烯生育酚治疗对体重、大脑氧化水平和认知功能的影响。结果表明，三烯生育酚治疗抑制了体重增加；此外，三烯生育酚到达大脑并减轻了 HFD 处理的老鼠的氧化。这些结果表明，三烯生育酚具有抗肥胖作用，并抑制肥胖引起的大脑氧化。
