Molecular Cell Biology Laboratory, Department of Bioscience and Engineering, College of System Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan.
Dydo-Takenaka Beverage Co., Ltd., Haneyou Ko 1310-1, Muroto 781-6741, Japan.
Nutrients. 2022 Apr 25;14(9):1794. doi: 10.3390/nu14091794.
Deep-sea water (DSW) contains multiple minerals and is widely used as drinking water, for cosmetic purposes, and as seasoning. In this study, several types of extract-added water with different levels of hardness (200, 300, 500) were prepared from DSW collected off the coast of Muroto City, Kochi Prefecture. We administrated it to obese mice for two months and tested it for several effects. Although there was no anti-obesity effect for any hardness level in obese mice, the cognitive functions of each DSW-extract-added water-treated group were significantly improved compared to control obese mice in the water maze test. Time-to-fall by the rota-rod test was also dramatically improved in the DSW-extract-added water-treated groups. The levels of triglycerides and blood urea nitrogen were significantly decreased in DSW-extract-added water-treated obese mice. However, these results did not depend on the hardness. Hardness levels of 200 or 300 of DSW-extract-added water had greater effects on cognitive function and serum scores compared to a level of 500. We analyzed DSW using inductively coupled plasma atomic emission spectroscopy and inductively coupled plasma mass spectrometry. High concentrations of magnesium and potassium were detected, but sodium was not detected at very high concentrations. Although the detailed mechanisms of its effects are not yet understood, chronic intake of DSW-extract-added water may have a beneficial effect on health.
深海水（DSW）含有多种矿物质，被广泛用作饮用水、化妆品和调味料。在这项研究中，我们从高知县室户市沿海采集的 DSW 中制备了几种硬度（200、300、500）不同的添加提取物水。我们将其喂给肥胖小鼠两个月，并测试了它的几种效果。尽管在肥胖小鼠中，任何硬度水平都没有抗肥胖作用，但在水迷宫测试中，与对照肥胖小鼠相比，各 DSW-提取物添加水治疗组的认知功能显著提高。在旋转棒测试中，DSW-提取物添加水治疗组的跌倒时间也明显提高。肥胖小鼠的甘油三酯和血尿素氮水平也显著降低。然而，这些结果并不取决于硬度。与 500 硬度相比，DSW-提取物添加水的 200 或 300 硬度水平对认知功能和血清评分的影响更大。我们使用电感耦合等离子体原子发射光谱法和电感耦合等离子体质谱法分析了 DSW。检测到高浓度的镁和钾，但没有检测到非常高浓度的钠。尽管其作用的详细机制尚不清楚，但长期摄入 DSW-提取物添加水可能对健康有益。
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