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[KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions].[KatG基因Ser315Thr突变作为新西伯利亚和克麦罗沃地区分离出的结核分枝杆菌对异烟肼耐药的主要原因]
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A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide.katG S315T突变或ahpC启动子突变介导结核分枝杆菌对2-噻吩羧酸酰肼耐药，2-噻吩羧酸酰肼是一种类似于抗结核药物异烟肼和乙硫异烟胺的抑制剂。
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Genome sequencing of Mycobacterium tuberculosis clinical isolates revealed isoniazid resistance mechanisms undetected by conventional molecular methods.结核分枝杆菌临床分离株的基因组测序揭示了常规分子方法无法检测到的异烟肼耐药机制。
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The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan.台湾地区异烟肼耐药结核分枝杆菌分离株 katG 和 inhA 基因突变。
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Arginine-deprivation-induced oxidative damage sterilizes .精氨酸剥夺诱导的氧化损伤使 …… 失去生育能力。
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9779-9784. doi: 10.1073/pnas.1808874115. Epub 2018 Aug 24.
2
Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests.新型结核分枝杆菌异烟肼耐药突变的验证，这些突变不能通过常见的分子检测方法检出。
Antimicrob Agents Chemother. 2018 Sep 24;62(10). doi: 10.1128/AAC.00974-18. Print 2018 Oct.
3
Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.通过营养缺陷型合理设计生物安全二级（BSL-2）批准的、耐多药结核分枝杆菌菌株。
mBio. 2018 May 29;9(3):e00938-18. doi: 10.1128/mBio.00938-18.
4
Plasticity of NADH dehydrogenases and their role in virulence.NADH 脱氢酶的可塑性及其在毒力中的作用。
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1599-1604. doi: 10.1073/pnas.1721545115. Epub 2018 Jan 30.
5
Enhanced respiration prevents drug tolerance and drug resistance in .增强呼吸可预防 中的药物耐受性和抗药性。
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4495-4500. doi: 10.1073/pnas.1704376114. Epub 2017 Apr 10.
6
Whole genome analysis of an MDR Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions associated with resistance to isoniazid.一株具有与异烟肼耐药相关的大基因组缺失的耐多药北京/W型结核分枝杆菌的全基因组分析。
Gene. 2016 May 15;582(2):128-36. doi: 10.1016/j.gene.2016.02.003. Epub 2016 Feb 4.
7
The crucial role of l-arginine in macrophage activation: What you need to know about it.L-精氨酸在巨噬细胞激活中的关键作用：你需要了解的相关内容。
Life Sci. 2015 Sep 15;137:44-8. doi: 10.1016/j.lfs.2015.07.012. Epub 2015 Jul 17.
8
Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.鉴定与结核分枝杆菌高水平异烟肼耐药相关的 katG 突变。
Antimicrob Agents Chemother. 2010 May;54(5):1793-9. doi: 10.1128/AAC.01691-09. Epub 2010 Mar 8.
9
Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance.在体外筛选出的结核分枝杆菌耐药突变体并不能反映异烟肼耐药的体内机制。
J Antimicrob Chemother. 2009 Sep;64(3):515-23. doi: 10.1093/jac/dkp237. Epub 2009 Jul 4.
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Laboratory maintenance of Mycobacterium tuberculosis.结核分枝杆菌的实验室保存
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结核分枝杆菌对异烟肼耐药的大片段缺失突变体的特性分析

Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance.

作者信息

Vilchèze Catherine, Saranathan Rajagopalan, Weinrick Brian, Jacobs William R

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

出版信息

Antimicrob Agents Chemother. 2020 Aug 20;64(9). doi: 10.1128/AAC.00792-20.

DOI:10.1128/AAC.00792-20
PMID:32631825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7449219/
Abstract

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant mutants derived from four strains. These LGDs had no growth defect but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking The LGD regions comprise 74 genes, mostly of unknown function, that may be important for intracellular growth and protection against oxidative stress.

摘要

在源自四株菌株的异烟肼耐药突变体中观察到大片段基因组缺失（LGDs）（6至63千碱基对）。这些LGDs没有生长缺陷，但可能在细胞内生长方面存在缺陷，并且尽管缺乏某些基因，但对氧化应激表现出不同的敏感性。LGD区域包含74个基因，大多数功能未知，这些基因可能对细胞内生长和抵抗氧化应激很重要。