结核分枝杆菌对异烟肼耐药的大片段缺失突变体的特性分析
Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance.
作者信息
Vilchèze Catherine, Saranathan Rajagopalan, Weinrick Brian, Jacobs William R
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
出版信息
Antimicrob Agents Chemother. 2020 Aug 20;64(9). doi: 10.1128/AAC.00792-20.
Abstract
Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant mutants derived from four strains. These LGDs had no growth defect but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking The LGD regions comprise 74 genes, mostly of unknown function, that may be important for intracellular growth and protection against oxidative stress.
摘要
在源自四株菌株的异烟肼耐药突变体中观察到大片段基因组缺失（LGDs）（6至63千碱基对）。这些LGDs没有生长缺陷，但可能在细胞内生长方面存在缺陷，并且尽管缺乏某些基因，但对氧化应激表现出不同的敏感性。LGD区域包含74个基因，大多数功能未知，这些基因可能对细胞内生长和抵抗氧化应激很重要。
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