Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Gedung Nanizar Zaman Joenoes, Kampus C Unair, Surabaya, 60115, Indonesia.
J Nat Med. 2020 Sep;74(4):796-803. doi: 10.1007/s11418-020-01426-5. Epub 2020 Jul 6.
Two new tri-ferulates of sucrose, firmosides A and B (1 and 2, respectively), together with 18 known compounds (3-20), were isolated from the aerial parts of Silene firma. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D, 2D NMR, and high-resolution electro-spray ionization-mass spectrometry (HR-ESI-MS). All the isolated compounds were evaluated for their free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. As a result, two new compounds (1, 2) and 11 demonstrated significant radical scavenging activity, implying the usefulness as antioxidant agents.
从 firmosa 石竹的地上部分分离得到两种新的蔗糖三咖啡酸酯，即 firmosides A 和 B（分别为 1 和 2），以及 18 种已知化合物（3-20）。通过各种光谱方法，包括 1D、2D NMR 和高分辨率电喷雾电离质谱（HR-ESI-MS），阐明了分离化合物的结构。所有分离得到的化合物均采用 1,1-二苯基-2-苦基肼（DPPH）自由基评价其自由基清除活性。结果，两种新化合物（1、2）和 11 表现出显著的自由基清除活性，表明它们可用作抗氧化剂。
