Laboratoire de Génétique de l'Evolution, Chimie Biologie et Innovation, Université PSL, Paris, France.
Institut de Biologie de l'École Normale Supérieure (IBENS), École Normale Supérieure, Université PSL, Paris, France.
Elife. 2020 Jul 7;9:e53433. doi: 10.7554/eLife.53433.
Interactions among microbial cells can generate new chemistries and functions, but exploitation requires establishment of communities that reliably recapitulate community-level phenotypes. Using mechanistic mathematical models, we show how simple manipulations to population structure can exogenously impose Darwinian-like properties on communities. Such scaffolding causes communities to participate directly in the process of evolution by natural selection and drives the evolution of cell-level interactions to the point where, despite underlying stochasticity, derived communities give rise to offspring communities that faithfully re-establish parental phenotype. The mechanism is akin to a developmental process () that arises from density-dependent interactions among cells. Knowledge of ecological factors affecting evolution of developmental correction has implications for understanding the evolutionary origin of major egalitarian transitions, symbioses, and for top-down engineering of microbial communities.
微生物细胞之间的相互作用可以产生新的化学物质和功能，但要加以利用，就需要建立能够可靠重现群落水平表型的群落。我们使用基于机制的数学模型，展示了简单地改变种群结构如何能够将类似于达尔文的特性强加于群落。这种支架使群落通过自然选择直接参与进化过程，并促使细胞间相互作用的进化达到这样一个程度：尽管存在随机性，但衍生群落产生的后代群落忠实地再现了亲本的表型。这种机制类似于一种发育过程（），它是由细胞之间的密度依赖相互作用引起的。了解影响发育校正进化的生态因素，对于理解主要平等过渡、共生体的进化起源以及对微生物群落的自上而下的工程设计具有重要意义。
