Bennink J R, Yewdell J W
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852.
J Exp Med. 1988 Nov 1;168(5):1935-9. doi: 10.1084/jem.168.5.1935.
We determined the MHC restriction of CTL responses to five individual influenza virus proteins. Four viral proteins failed to be recognized in conjunction with three of the five class I alleles of the H-2k and H-2d haplotypes, while the fifth was recognized only in conjunction with a single allele. This indicates that there is a significant chance that a given class I allele will be associated with low responsiveness or nonresponsiveness for a given foreign protein. This explains, at least in part, why MHC-linked nonresponsiveness is frequently detected in polyclonal antiviral CTL responses. Most importantly, these findings support the idea that responsiveness to foreign antigens is a critical factor in maintaining the high degree of MHC class I polymorphism in outbred populations.
我们确定了细胞毒性T淋巴细胞（CTL）对五种流感病毒蛋白的反应的主要组织相容性复合体（MHC）限制。四种病毒蛋白无法与H-2k和H-2d单倍型的五个I类等位基因中的三个结合被识别，而第五种蛋白仅与一个等位基因结合被识别。这表明对于给定的外来蛋白，特定的I类等位基因很有可能与低反应性或无反应性相关。这至少部分解释了为什么在多克隆抗病毒CTL反应中经常检测到与MHC相关的无反应性。最重要的是，这些发现支持了对外来抗原的反应性是维持远交群体中I类MHC高度多态性的关键因素这一观点。
