Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, 40530 Gothenburg, Sweden.
Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41686 Gothenburg, Sweden.
Nutrients. 2020 Jul 5;12(7):1996. doi: 10.3390/nu12071996.
Fetal and early postnatal inflammation have been associated with increased morbidity in extremely preterm infants. This study aimed to demonstrate if postpartum levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) were associated with early inflammation. In a cohort of 90 extremely preterm infants, DHA and AA in cord blood, on the first postnatal day and on postnatal day 7 were examined in relation to early systemic inflammation, defined as elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) within 72 h from birth, with or without positive blood culture. Median serum level of DHA was 0.5 mol% (95% CI (confidence interval) 0.2-0.9, = 0.006) lower than the first postnatal day in infants with early systemic inflammation, compared to infants without signs of inflammation, whereas levels of AA were not statistically different between infants with and without signs of inflammation. In cord blood, lower serum levels of both DHA (correlation coefficient -0.40; = 0.010) and AA (correlation coefficient -0.54; < 0.001) correlated with higher levels of IL-6. Levels of DHA or AA did not differ between infants with and without histological signs of chorioamnionitis or fetal inflammation. In conclusion, serum levels of DHA at birth were associated with the inflammatory response during the early postnatal period in extremely preterm infants.
胎儿和早期产后炎症与极早产儿发病率增加有关。本研究旨在证明产后二十二碳六烯酸 (DHA) 和花生四烯酸 (AA) 水平是否与早期炎症有关。在 90 名极早产儿队列中，在脐带血、出生后第 1 天和第 7 天检查了 DHA 和 AA 水平，以确定早期全身炎症，定义为出生后 72 小时内 C 反应蛋白 (CRP) 和/或白细胞介素 6 (IL-6) 升高，无论是否有阳性血培养。与无炎症迹象的婴儿相比，在出生后早期发生全身炎症的婴儿中，血清 DHA 中位数水平低 0.5 毫摩尔%（95%置信区间 (CI) 0.2-0.9， = 0.006），而 AA 水平在有炎症和无炎症迹象的婴儿之间无统计学差异。在脐带血中，DHA（相关系数 -0.40； = 0.010）和 AA（相关系数 -0.54； < 0.001）的血清水平较低与较高的 IL-6 水平相关。有或没有组织学绒毛膜羊膜炎或胎儿炎症迹象的婴儿之间 DHA 或 AA 水平没有差异。总之，出生时的 DHA 血清水平与极早产儿出生后早期的炎症反应有关。
