茶多酚通过调节肥胖相关基因和下调高脂肪喂养犬 COX-2 和 iNOS 表达来减轻肝脏炎症。
Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs.
机构信息
College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China.
School of Tea and Food Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China.
出版信息
BMC Vet Res. 2020 Jul 8;16(1):234. doi: 10.1186/s12917-020-02448-7.
BACKGROUND
Tea polyphenols (TPs) attenuate obesity related liver inflammation; however, the anti-obesity effects and anti-inflammatory mechanisms are not clearly understood. This study aimed to determine whether the anti-obesity and anti-inflammatory TPs mechanisms associated with cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression levels, and obesity-related gene response in dogs.
RESULTS
Dogs fed TPs displayed significantly decreased (p < 0.01) mRNA expression of tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) compared to dogs that consumed high-fat diet (HFD) alone. TPs significantly (p < 0.01) inhibited COX-2 and iNOS expression level, and decreased liver fat content and degeneration.
CONCLUSION
These results suggested that TPs act as a therapeutic agent for obesity, liver inflammation, and fat degeneration via COX-2 and iNOS inhibition, with TNF-α, IL-1β, and IL-6 involvement.
背景
茶多酚（TPs）可减轻肥胖相关的肝脏炎症；然而，其抗肥胖作用和抗炎机制尚不清楚。本研究旨在确定 TPs 是否通过环氧化酶-2（COX-2）和诱导型一氧化氮合酶（iNOS）表达水平以及与肥胖相关的基因反应来发挥其抗肥胖和抗炎作用。
结果
与单独食用高脂肪饮食（HFD）的狗相比，喂食 TPs 的狗的肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）mRNA 表达显著降低（p<0.01）。TPs 显著（p<0.01）抑制 COX-2 和 iNOS 表达水平，并降低肝脏脂肪含量和变性。
结论
这些结果表明，TPs 通过抑制 COX-2 和 iNOS 以及 TNF-α、IL-1β 和 IL-6 的参与，发挥治疗肥胖、肝脏炎症和脂肪变性的作用。
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