制药公司中的实验动物过敏
Laboratory animal allergy in a pharmaceutical company.
作者信息
Venables K M, Tee R D, Hawkins E R, Gordon D J, Wale C J, Farrer N M, Lam T H, Baxter P J, Newman Taylor A J
机构信息
Department of Occupational Medicine, Cardiothoracic Institute, London, UK.
出版信息
Br J Ind Med. 1988 Oct;45(10):660-6. doi: 10.1136/oem.45.10.660.
A cross sectional survey was carried out on 138 workers exposed to laboratory animals. Sixty (44%) had symptoms in a self completed questionnaire that were consistent with laboratory animal allergy (LAA) of whom 15 (11%) had chest symptoms. There was a positive skin prick test to one or more animal urine extracts (rat, mouse, guinea pig, rabbit) in 13% and 38% had a positive radioallergosorbent test to urine extract. LAA chest symptoms were almost five times more common in atopic than non-atopic subjects (who were distinguished by skin test response to common, non-animal aeroallergens). A positive skin test to animal urine was associated with LAA chest symptoms and with atopy. Nose, eye, or skin symptoms without chest symptoms were not associated with atopy. There was an inverse relation between duration of employment at the firm and LAA chest symptoms, suggesting selection of affected people out of employment with animals.
对138名接触实验动物的工人进行了横断面调查。在一份自我填写的问卷中，60人（44%）出现了与实验动物过敏（LAA）相符的症状，其中15人（11%）有胸部症状。13%的人对一种或多种动物尿液提取物（大鼠、小鼠、豚鼠、兔子）皮肤点刺试验呈阳性，38%的人对尿液提取物放射性变应原吸附试验呈阳性。LAA胸部症状在特应性个体中比非特应性个体（通过对常见非动物气传变应原的皮肤试验反应区分）几乎常见五倍。对动物尿液皮肤试验呈阳性与LAA胸部症状和特应性相关。无胸部症状的鼻、眼或皮肤症状与特应性无关。在公司的工作时长与LAA胸部症状之间存在负相关关系，提示受影响的人会从与动物相关的工作中被筛选出来。
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