吸烟、特应性和实验动物过敏。
Smoking, atopy, and laboratory animal allergy.
作者信息
Venables K M, Upton J L, Hawkins E R, Tee R D, Longbottom J L, Newman Taylor A J
机构信息
Department of Occupational Medicine, Brompton Hospital, London, UK.
出版信息
Br J Ind Med. 1988 Oct;45(10):667-71. doi: 10.1136/oem.45.10.667.
Abstract
This study examined data from three cross sectional surveys of 296 laboratory workers exposed to small mammals. Four indices of laboratory animal allergy were studied: symptoms suggestive of occupational asthma, symptoms suggestive of any occupational allergy, skin weals to animal urine extracts, and serum binding in radioallergosorbent tests with urine extracts. Pooled data from the three surveys showed an association between smoking and all indices except radioallergosorbent tests; the association was significant for symptoms of occupational asthma. One of the three surveys consistently showed a stronger association of allergy indices with smoking than with atopy (defined on skin tests with non-animal aeroallergens). Associations with smoking persisted after stratifying by atopic status, suggesting that smoking may be a risk factor for laboratory animal allergy.
摘要
本研究分析了对296名接触小型哺乳动物的实验室工作人员进行的三项横断面调查的数据。研究了四项实验室动物过敏指标：提示职业性哮喘的症状、提示任何职业性过敏的症状、对动物尿液提取物的皮肤风团，以及用尿液提取物进行的放射变应原吸附试验中的血清结合情况。三项调查的汇总数据显示，吸烟与除放射变应原吸附试验外的所有指标之间均存在关联；职业性哮喘症状的关联具有显著性。三项调查之一始终显示，过敏指标与吸烟的关联比与特应性（通过对非动物气传变应原进行皮肤试验定义）的关联更强。按特应性状态分层后，与吸烟的关联依然存在，这表明吸烟可能是实验室动物过敏的一个风险因素。
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