Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Department of Mechanical Engineering, Shahid Rajaee Teacher Training University, Shabanloo Street, Tehran, 16788, Iran.
J Mater Sci Mater Med. 2020 Jul 8;31(7):60. doi: 10.1007/s10856-020-06398-2.
Recently, nanomaterials have been widely utilized in tissue engineering applications due to their unique properties such as the high surface to volume ratio and diversity of morphology and structure. However, most methods used for the fabrication of nanomaterials are rather complicated and costly. Among different nanomaterials, anodic aluminum oxide (AAO) is a great example of nanoporous structures that can easily be engineered by changing the electrolyte type, anodizing potential, current density, temperature, acid concentration and anodizing time. Nanoporous anodic alumina has often been used for mammalian cell culture, biofunctionalization, drug delivery, and biosensing by coating its surface with biocompatible materials. Despite its wide application in tissue engineering, thorough in vivo and in vitro studies of AAO are still required to enhance its biocompatibility and thereby pave the way for its application in tissue replacements. Recognizing this gap, this review article aims to highlight the biomedical potentials of AAO for applications in tissue replacements along with the mechanism of porous structure formation and pore characteristics in terms of fabrication parameters.
最近，由于纳米材料具有高的比表面积和形态与结构的多样性等独特性质，它们已被广泛应用于组织工程学领域。然而，大多数用于制备纳米材料的方法都相当复杂且昂贵。在不同的纳米材料中，阳极氧化铝（AAO）是一种很好的纳米多孔结构的例子，通过改变电解液类型、阳极氧化电势、电流密度、温度、酸浓度和阳极氧化时间，可以很容易地对其进行工程设计。纳米多孔阳极氧化铝经常被用于哺乳动物细胞培养、生物功能化、药物输送和生物传感，其表面涂覆有生物相容性材料。尽管它在组织工程学中有广泛的应用，但仍需要对 AAO 进行彻底的体内和体外研究，以提高其生物相容性，从而为其在组织替代物中的应用铺平道路。认识到这一差距，本文旨在强调 AAO 在组织替代物应用中的生物医学潜力，以及多孔结构形成的机制和制造参数方面的孔径特征。
