Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Institute of Neurobiology, University of Lübeck, Lübeck, Germany.
Elife. 2020 Jul 9;9:e55388. doi: 10.7554/eLife.55388.
Endogenous circadian clocks have evolved to anticipate 24 hr rhythms in environmental demands. Recent studies suggest that circadian rhythm disruption is a major risk factor for the development of metabolic disorders in humans. Conversely, alterations in energy state can disrupt circadian rhythms of behavior and physiology, creating a vicious circle of metabolic dysfunction. How peripheral energy state affects diurnal food intake, however, is still poorly understood. We here show that the adipokine adiponectin (ADIPOQ) regulates diurnal feeding rhythms through clocks in energy regulatory centers of the mediobasal hypothalamus (MBH). -deficient mice show increased rest phase food intake associated with disrupted transcript rhythms of clock and appetite-regulating genes in the MBH. ADIPOQ regulates MBH clocks AdipoR1-mediated upregulation of the core clock gene . BMAL1, in turn, controls expression of orexigenic neuropeptide expression in the MBH. Together, these data reveal a systemic metabolic circuit to regulate central circadian clocks and energy intake.
内源性生物钟已经进化到可以预测环境需求的 24 小时节律。最近的研究表明，生物钟紊乱是人类代谢紊乱发展的一个主要危险因素。相反，能量状态的改变会破坏行为和生理的昼夜节律，形成代谢功能障碍的恶性循环。然而，外周能量状态如何影响日间食物摄入仍知之甚少。我们在这里表明，脂肪因子脂联素（ADIPOQ）通过中脑基底部（MBH）的能量调节中枢的时钟来调节昼夜摄食节律。ADIPOQ 调节 MBH 时钟 ADIPOR1 介导的核心时钟基因 的上调。BMAL1 反过来控制 MBH 中食欲调节神经肽的表达。这些数据共同揭示了一个系统的代谢回路，以调节中枢生物钟和能量摄入。
