Zhao Hongbo, Liu Min, Zhang Yajie, Yin Jingbo, Pei Renjun
Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China and CAS Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056, China.
Nanoscale. 2020 Jul 23;12(28):14976-14995. doi: 10.1039/d0nr03785k.
Tissue engineering is an important field of regenerative medicine, which combines scaffolds and cell transplantation to develop substitute tissues and/or promote tissue regeneration. Hydrogels, a three-dimensional network with high water content and biocompatibility, have been widely used as scaffolds to mimic the structure and properties of tissues. However, the low mechanical strength and limited functions of traditional hydrogels greatly limited their applications in tissue engineering. Recently, nanocomposite hydrogels, with its advantages of high mechanical property and some unique properties (such as electrical conductivity, antibacterial, antioxidation, magnetic responsiveness), have emerged as the most versatile and innovative technology, which provides a new opportunity as a unique tool for fabricating hydrogels with excellent properties. In this review, we summarize the recent advances in fabricating nanocomposite hydrogels and their applications in tissue engineering. In addition, the future and prospects of nanocomposite hydrogels for tissue engineering are also discussed.
组织工程是再生医学的一个重要领域，它将支架与细胞移植相结合，以开发替代组织和/或促进组织再生。水凝胶是一种具有高含水量和生物相容性的三维网络，已被广泛用作支架来模拟组织的结构和特性。然而，传统水凝胶的低机械强度和有限功能极大地限制了它们在组织工程中的应用。近年来，纳米复合水凝胶凭借其高机械性能和一些独特性能（如导电性抗菌、抗氧化、磁响应性）的优势，成为最具通用性和创新性的技术，为制造具有优异性能的水凝胶提供了一种独特工具的新机遇。在本综述中，我们总结了制备纳米复合水凝胶的最新进展及其在组织工程中的应用。此外，还讨论了纳米复合水凝胶在组织工程中的未来发展和前景。
