Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
ACS Infect Dis. 2020 Jul 10;6(7):1567-1571. doi: 10.1021/acsinfecdis.0c00342. Epub 2020 Jun 11.
Bacterial infections are urgent threats to human health, especially in light of rising rates of antibiotic resistance, and their ubiquity demands the development of efficient diagnostic platforms. Electrochemical biosensors for point-of-care testing are garnering interest due to their speed, sensitivity, and selectivity as well as their inexpensive, user-friendly operation. These biosensors have the potential to make significant commercial and clinical impacts. In this Viewpoint, we discuss recent advances in the electrochemical detection of pathogenic bacteria using both direct and alternating current. We focus on platforms that detect whole microbes, as these sensors are specific, fast, and easy to operate.
细菌感染对人类健康构成紧迫威胁,尤其是在抗生素耐药率不断上升的情况下,而细菌的普遍存在要求开发高效的诊断平台。电化学生物传感器因其速度、灵敏度和选择性以及低成本、用户友好的操作而引起了人们的兴趣,可用于即时检测。这些生物传感器具有产生重大商业和临床影响的潜力。在本观点中,我们讨论了使用直流和交流电进行电化学检测致病菌的最新进展。我们重点介绍了检测整个微生物的平台,因为这些传感器具有特异性、快速和易于操作的特点。