Department of Ophthalmology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yotsuya Shirato Eye Clinic, 1-1-2 Yotsuya, Shinjuku-ku, Tokyo, Japan.
Sci Rep. 2022 Apr 9;12(1):5991. doi: 10.1038/s41598-022-10033-1.
This study aimed to evaluate the diagnostic ability and sectoral structure function relationship of circumpapillary vessel density (cpVD) and macular vessel density (mVD) with optical coherence tomography angiography (OCTA) in early glaucomatous (EG) eyes. 224 EG eyes of 167 patients (mean deviation (MD) > - 6 dB) and 70 normal eyes of 70 subjects were enrolled in this retrospective cross-sectional study. All patients underwent OCT and OCTA scanning. Diagnostic abilities were evaluated with area under receiver operating characteristic curves (AUROC). Structure function relationships of superior, inferior and Garway-Heath sectoral values with its corresponding visual field (VF) sensitivity were determined using linear mixed models. AUROCs were 0.798, 0.621, 0.876 and 0.835 for cpVD, mVD, circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and ganglion cell-inner plexiform layer, respectively. AUROC of cpVD was significantly lower than cpRNFLT (P = 0.010) and higher than mVD (P < 0.001). All Garway-Heath sectors of cpVD significantly correlated with its corresponding VF sensitivity except for the nasal sector. MVD also showed significant structure function relationship and the correlations were stronger in the perifoveal region (6 mm annulus) than in the parafoveal region (3 mm annulus). CpVD demonstrated moderate diagnostic ability and both cpVD and mVD demonstrated significant association with VF sensitivity in EG eyes.
本研究旨在评估光学相干断层扫描血管造影（OCTA）的脉络膜周血管密度（cpVD）和黄斑血管密度（mVD）在早期青光眼（EG）眼中的诊断能力和节段结构功能关系。本回顾性横断面研究纳入了 167 名患者的 224 只 EG 眼（平均偏差（MD）＞-6dB）和 70 名对照者的 70 只正常眼。所有患者均接受了 OCT 和 OCTA 扫描。采用受试者工作特征曲线下面积（AUROC）评估诊断能力。采用线性混合模型确定上、下和 Garway-Heath 节段值与相应视野（VF）敏感性的结构功能关系。cpVD、mVD、脉络膜周视网膜神经纤维层厚度（cpRNFLT）和神经节细胞-内丛状层的 AUROC 分别为 0.798、0.621、0.876 和 0.835。cpVD 的 AUROC 显著低于 cpRNFLT（P=0.010），高于 mVD（P＜0.001）。cpVD 的所有 Garway-Heath 节段均与相应的 VF 敏感性显著相关，除了鼻侧节段。mVD 也显示出显著的结构功能关系，并且在中心凹旁（6mm 环）比中心凹（3mm 环）的相关性更强。cpVD 具有中等的诊断能力，cpVD 和 mVD 在 EG 眼中均与 VF 敏感性有显著相关性。
