Raffn E, Mikkelsen S, Altman D G, Christensen J M, Groth S
Department of Occupational Medicine, Danish Labour Inspectorate, Copenhagen, Denmark.
Scand J Work Environ Health. 1988 Dec;14(6):378-84. doi: 10.5271/sjweh.1903.
Forty-six plate painters, heavily exposed to cobalt blue dye, took part in this cross-sectional study, and 51 top-glaze painters served as the referents. The study comprised a questionnaire, a health examination, a lung function test, and the determination of the blood and urinary cobalt levels. The plate painters were examined twice, at the end of a workfree period and after resuming work. More plate painters complained of irritation from the mucous membranes in the mouth and throat, cough, and expectoration than the referents. The symptoms increased after the plate painters resumed work. The cobalt level of the plate-painting group after six weeks off work was twice as high in the blood and five times higher in the urine than the corresponding values of the reference group. After the plate painters resumed work, the blood and urinary levels increased approximately 4 and 15 times, respectively. Increased airflow resistance was found in the plate group when compared with the referents, and signs of small airway obstruction increased after the plate painters resumed work. The pulse rate was higher among the plate painters, and minor changes in the red blood cell picture were observed. None of these adverse health effects were associated with the cobalt levels in the blood or urine.
46名大量接触钴蓝染料的制版工参与了这项横断面研究，51名面釉工作为对照。该研究包括问卷调查、健康检查、肺功能测试以及血液和尿液中钴含量的测定。制版工在一段非工作期结束时和重新工作后接受了两次检查。与对照组相比，更多的制版工抱怨口腔和咽喉黏膜有刺激感、咳嗽和咳痰。制版工重新工作后症状加重。离岗六周后，制版工组的血液钴含量是对照组相应值的两倍，尿液钴含量是对照组的五倍。制版工重新工作后，血液和尿液中的钴含量分别增加了约4倍和15倍。与对照组相比，制版工组的气流阻力增加，重新工作后小气道阻塞的迹象增多。制版工的脉搏率较高，红细胞图像有轻微变化。这些不良健康影响均与血液或尿液中的钴含量无关。
