Razavi Alexander C, Bazzano Lydia A, He Jiang, Whelton Seamus P, Rebholz Casey M, Fernandez Camilo, Krousel-Wood Marie, Li Changwei, Shi Mengyao, Nierenberg Jovia L, Li Shengxu, Kinchen Jason, Mi Xuenan, Kelly Tanika N
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine.
Department of Medicine, Tulane University School of Medicine.
J Hypertens. 2020 Dec;38(12):2435-2442. doi: 10.1097/HJH.0000000000002571.
Dietary factors mediate racial disparities in hypertension. However, the physiological mechanisms underlying this relationship are incompletely understood. We sought to assess the association between 1-methylhistidine (1-MH), a metabolite marker of animal protein consumption, and blood pressure (BP) in a community-based cohort of black and white middle-aged adults.
This analysis consisted of 655 participants of the Bogalusa Heart Study (25% black, 61% women, aged 34-58 years) who were not taking antihypertensive medication. Fasting serum 1-MH was measured using liquid chromatography-tandem mass spectroscopy. Animal food intakes were quantified by food-frequency questionnaires. Multivariable linear regression assessed the association between 1-MH and BP in combined and race-stratified analyses, adjusting for demographic, dietary, and cardiometabolic factors.
A significant dose--response relationship was observed for the association of red meat (P-trend <0.01) and poultry (P-trend = 0.03) intake with serum 1-MH among all individuals. Serum 1-MH, per standard deviation increase, had a significant positive association with SBP (β=3.4 ± 1.6 mmHg, P = 0.04) and DBP (β=2.0 ± 1.1 mmHg, P = 0.05) in black participants, whereas no appreciable association was observed in white participants. Among a subgroup of black participants with repeat outcome measures (median follow-up = 3.0 years), one standard deviation increase in 1-MH conferred a 3.1 and 2.2 mmHg higher annual increase in SBP (P = 0.03) and DBP (P = 0.03), respectively.
Serum 1-MH associates with higher SBP and DBP in blacks, but not whites. These results suggest a utility for further assessing the role of dietary 1-MH among individuals with hypertension to help minimize racial disparities in cardiovascular health.
饮食因素介导高血压的种族差异。然而，这种关系背后的生理机制尚未完全明确。我们试图在一个以社区为基础的黑人和白人中年成年人队列中，评估动物蛋白摄入的代谢物标志物1-甲基组氨酸（1-MH）与血压（BP）之间的关联。
该分析纳入了655名未服用抗高血压药物的博加卢萨心脏研究参与者（25%为黑人，61%为女性，年龄34 - 58岁）。使用液相色谱 - 串联质谱法测量空腹血清1-MH。通过食物频率问卷对动物性食物摄入量进行量化。多变量线性回归在综合分析和按种族分层分析中评估1-MH与血压之间的关联，并对人口统计学、饮食和心脏代谢因素进行调整。
在所有个体中，红肉（P趋势<0.01）和家禽（P趋势 = 0.03）摄入量与血清1-MH的关联呈现显著的剂量 - 反应关系。在黑人参与者中，血清1-MH每增加一个标准差，与收缩压（β = 3.4 ± 1.6 mmHg，P = 0.04）和舒张压（β = 2.0 ± 1.1 mmHg，P = 0.05）呈显著正相关，而在白人参与者中未观察到明显关联。在有重复结局测量的黑人参与者亚组中（中位随访 = 3.0年），1-MH每增加一个标准差，收缩压（P = 0.03）和舒张压（P = 0.03）的年增幅分别高出3.1和2.2 mmHg。
血清1-MH与黑人的较高收缩压和舒张压相关，但与白人无关。这些结果表明，进一步评估饮食中1-MH在高血压个体中的作用，有助于减少心血管健康方面的种族差异。
