Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Faculty of Health Sciences, Rey Juan Carlos University, Avenida de Atenas s/n 28922 Alcorcón, Madrid, Spain.
Robotics Lab. University Carlos III of Madrid, Leganés, Madrid, Spain.
J Neuroeng Rehabil. 2020 Jul 13;17(1):90. doi: 10.1186/s12984-020-00718-x.
Dexterity and activities of daily living limitations on the upper limb (UL) represent one of the most common problems in patients with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of the specially developed Serious Games that make use of the Leap Motion Controller (LMC) as main user interface for improving UL grip muscle strength, dexterity, fatigue, quality of life, satisfaction and compliance.
A single-blinded randomized controlled trial was conducted. The sample was randomized into two groups: an experimental group who received treatment based on serious games designed by the research team using the developed LMC based Serious Games for the UL plus conventional rehabilitation, and a control group who received the same conventional rehabilitation for the UL. Both groups received two 60 min sessions per week over a ten-week period. Grip muscle strength, coordination, speed of movements, fine and gross UL dexterity, fatigue, quality of life, satisfaction and compliance were assessed in both groups pre-treatment, post-treatment and in a follow-up period of 1 month without receiving any treatment.
In the experimental group compared to the control group, significant improvements were observed in the post-treatment assessment for coordination, speed of movements, fine and gross UL dexterity. Also, significant results were found in the follow-up in coordination, speed of movements, fine and gross for the more affected side.
An experimental protocol using an LMC based Serious Games designed for UL rehabilitation showed improvements for unilateral gross manual dexterity, fine manual dexterity, and coordination in MS patients with high satisfaction and excellent compliance.
This randomized controlled trial has been registered at ClinicalTrials.gov Identifier: NCT04171908 , Nov 2019.
上肢（UL）的灵巧性和日常生活活动能力受限是多发性硬化症（MS）患者最常见的问题之一。本研究旨在评估专门开发的利用 Leap Motion Controller（LMC）作为主要用户界面的严肃游戏对改善 UL 握力、灵巧性、疲劳、生活质量、满意度和依从性的有效性。
采用单盲随机对照试验。将样本随机分为两组：实验组接受基于由研究团队设计的严肃游戏的治疗，该游戏使用开发的基于 LMC 的严肃游戏治疗 UL 并结合常规康复治疗，对照组接受相同的 UL 常规康复治疗。两组均在十周内每周接受两次 60 分钟的治疗。在治疗前、治疗后和一个月的随访期内，评估两组的握力、协调性、运动速度、精细和粗大 UL 灵巧性、疲劳、生活质量、满意度和依从性。
与对照组相比，实验组在治疗后评估中协调能力、运动速度、精细和粗大 UL 灵巧性显著提高。此外，在随访中，在协调性、运动速度、精细和粗大方面，更受影响的一侧也有显著结果。
一项使用针对 UL 康复设计的基于 LMC 的严肃游戏的实验方案显示，在患有 MS 的患者中，单侧粗大手动灵巧性、精细手动灵巧性和协调性得到改善，满意度高，依从性好。
本随机对照试验已在 ClinicalTrials.gov 注册，标识符：NCT04171908，2019 年 11 月。
