State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, College of Chemical Engineering and Technology, Hainan University, Haikou, 570228, P. R. China.
ChemSusChem. 2020 Sep 18;13(18):4776-4794. doi: 10.1002/cssc.202001165. Epub 2020 Aug 13.
Alkynes are among the most fundamentally important organic compounds and are widely used in synthetic chemistry, biochemistry, and materials science. Thus, the development of an efficient and sustainable method for the preparation of alkynes has been a central concern in organic synthesis. Cross-dehydrogenative coupling utilizing E-H and Z-H bonds in two different molecules can avoid the need for prefunctionalization of starting materials and has become one of the most straightforward methods for the construction of E-Z chemical bonds. This Review summarizes recent progress in the preparation of internal alkynes by cross-dehydrogenative coupling with terminal alkynes.
炔烃是最重要的有机化合物之一，广泛应用于合成化学、生物化学和材料科学。因此，开发一种高效、可持续的炔烃制备方法一直是有机合成的核心关注点。利用两个不同分子中的 E-H 和 Z-H 键的交叉脱氢偶联可以避免起始原料的预官能化，已成为构建 E-Z 化学键的最直接方法之一。本文综述了通过末端炔烃的交叉脱氢偶联制备内部炔烃的最新进展。
