Graduate Programme of Health Sciences, Faculty of Medicine, Federal University of Uberlândia, Av. Pará, 1720, Bloco 2U, Campus Umuarama, Uberlândia 38405-320, Minas Gerais, Brazil.
Nutrients. 2020 Jul 13;12(7):2071. doi: 10.3390/nu12072071.
The aim of this study was to compare the acute effect of a high-protein/moderate carbohydrate (HP-MCHO) versus low-protein/high-carbohydrate (LP-HCHO) meal served at night on the postprandial metabolic response of male night workers the following breakfast. A randomized crossover study was performed with 14 male night workers (40.9 ± 8.9 years old; 29.1 ± 5.3 kg/m). Participants underwent two different isocaloric dietary conditions at 1:00 h of the night shift: HP-MCHO (45 en% carbohydrate, 35 en% protein and 20 en% fat) and LP-HCHO (65 en% carbohydrate, 15 en% protein and 20 en% fat). Postprandial capillary glucose levels were determined immediately before the intake of the test meal and 30, 60, 90 and 120 min after the end of the meal. At the end of the work shift (6:30 h), participants received a standard breakfast and postprandial levels of glucose, insulin and triglycerides were determined immediately before and then every 30 min for 2 h (30, 60, 90 and 120 min). Higher values of capillary glucose were found after the LP-HCHO condition compared to the HP-MCHO condition (area under the curve (AUC) = 119.46 ± 1.49 mg/dL × min and 102.95 ± 1.28 mg/dL × min, respectively; < 0.001). For the metabolic response to standard breakfast as the following meal, no significant differences in glucose, insulin, triglyceride, and HOMA-IR levels were found between interventions. A night meal with a higher percentage of protein and a lower percentage of carbohydrate led to minor postprandial glucose levels during the night shift but exerted no effect on the metabolic response of the following meal. This trial was registered at ClinicalTrials.gov as NCT03456219.
本研究旨在比较男性夜间工作者夜间食用高蛋白/中等碳水化合物（HP-MCHO）与低蛋白/高碳水化合物（LP-HCHO）餐对次日早餐后餐后代谢反应的急性影响。采用随机交叉研究，纳入 14 名男性夜间工作者（40.9 ± 8.9 岁；29.1 ± 5.3 kg/m）。参与者在夜班 1:00 时接受两种不同等热量饮食条件：HP-MCHO（45%碳水化合物、35%蛋白质和 20%脂肪）和 LP-HCHO（65%碳水化合物、15%蛋白质和 20%脂肪）。在摄入测试餐之前和结束后 30、60、90 和 120 分钟测定餐后毛细血管葡萄糖水平。在工作班次结束时（6:30），参与者立即接受标准早餐，并在之后的 2 小时内每 30 分钟测定一次血糖、胰岛素和甘油三酯水平（30、60、90 和 120 分钟）。与 HP-MCHO 条件相比，LP-HCHO 条件后毛细血管葡萄糖水平更高（曲线下面积（AUC）分别为 119.46 ± 1.49 mg/dL × min 和 102.95 ± 1.28 mg/dL × min；<0.001）。对于标准早餐作为下一顿餐的代谢反应，两种干预措施之间血糖、胰岛素、甘油三酯和 HOMA-IR 水平无显著差异。夜间餐中蛋白质比例较高、碳水化合物比例较低可导致夜间血糖水平较低，但对下一顿餐的代谢反应无影响。本试验在 ClinicalTrials.gov 注册为 NCT03456219。
