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意大利马群中Ca血型及同种抗体的流行情况

Prevalence of Ca Blood Type and Alloantibodies in a Population of Horses from Italy.

作者信息

Proverbio Daniela, Perego Roberta, Baggiani Luciana, Ferrucci Francesco, Zucca Enrica, Nobile Federico, Spada Eva

机构信息

Veterinary Transfusion Research Laboratory (REVLab), Department of Veterinary Medicine (DIMEVET), University of Milan, via dell'Università 6, 26900 Lodi, Italy.

Department of Health, Animal Science and Food Safety (VESPA), University of Milan, via dell'Università 6, 26900 Lodi, Italy.

出版信息

Animals (Basel). 2020 Jul 13;10(7):1179. doi: 10.3390/ani10071179.

Abstract

A knowledge of the blood groups and alloantibodies present is essential for the safe transfusion of blood products in horses. Pre-transfusion screening and blood typing minimizes the risk of incompatible RBC transfusions and prevents immunization of the recipient against incompatible RBC antigens. The frequencies of blood groups can vary among different breeds. Knowledge of a breed's blood group prevalence can be very useful for identifying the best blood donors during transfusion in clinical practice. The aims of this study were to estimate the prevalence of the Ca blood type in horses from Italy using a monoclonal immunocromatographic method and to estimate the prevalence of anti-Ca alloantibodies in Ca- horses using agglutination on gel technique. Ca blood type was determined on 110 whole blood samples. The prevalence of the Ca+ blood type was 79.1%. This study also provides data about the prevalence of Ca+ blood group in Italian Saddle Horses (77,3%) and Dutch Warmblood (58,3%). No significant association was found between Ca blood type and sex with 79.5% and 78.8% of females and males testing Ca+, respectively. The total number of Ca- samples with detectable anti-Ca alloantibodies was 7/23 (30.4%).

摘要

了解马匹中存在的血型和同种抗体对于安全输血至关重要。输血前筛查和血型鉴定可将不相容红细胞输血的风险降至最低,并防止受血者针对不相容红细胞抗原产生免疫反应。不同品种的血型频率可能有所不同。了解某个品种的血型流行情况对于在临床实践中输血时确定最佳供血者非常有用。本研究的目的是使用单克隆免疫层析法估计意大利马匹中Ca血型的流行率,并使用凝胶凝集技术估计Ca阴性马匹中抗Ca同种抗体的流行率。对110份全血样本进行了Ca血型测定。Ca阳性血型的流行率为79.1%。本研究还提供了意大利鞍马(77.3%)和荷兰温血马(58.3%)中Ca阳性血型流行率的数据。未发现Ca血型与性别之间存在显著关联,雌性和雄性检测为Ca阳性的比例分别为79.5%和78.8%。可检测到抗Ca同种抗体的Ca阴性样本总数为7/23(30.4%)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d41/7401544/583a72c67842/animals-10-01179-g001.jpg

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