基于植物的 CrO 纳米颗粒在多功能生物医学中的应用
Phyto-fabricated CrO nanoparticle for multifunctional biomedical applications.
机构信息
UNESCO UNISA Africa Chair in Nanosciences & Nanotechnology, College of Graduate Studies, University of South Africa (UNISA), Pretoria, South Africa.
NANOAFNET (Nanosciences African Network), Materials Research Department, iThemba LABS, Cape Town, South Africa.
出版信息
Nanomedicine (Lond). 2020 Jul;15(17):1653-1669. doi: 10.2217/nnm-2020-0129. Epub 2020 Jul 16.
The biosynthesis of chromium oxide nanoparticles (CrO NPs), using as a bioreductant, for assessment of their potential nanomedicinal applications. Biosynthesized CrO NPs were characterized by x-ray diffraction, Fourier-transform infrared spectroscopy, energy dispersive x-ray spectroscopy, scanning and transmission electron microscopy, selected area electron diffraction, UV-Vis spectroscopy and ζ-potential measurement. assays were used to assess the biological properties of CrO NPs. Nanoparticles with size approximately 25-38 nm were obtained with a characteristic Cr-O vibration at 417 cm. A broad spectrum antimicrobial potential and antioxidant nature is reported. Slight inhibition of polio virus and biocompatibility at low doses was observed. We conclude a multifunctional nature of biogenic CrO NPs.
使用 作为生物还原剂合成氧化铬纳米粒子（CrO NPs），评估其在纳米医药中的潜在应用。通过 X 射线衍射、傅里叶变换红外光谱、能量色散 X 射线能谱、扫描和透射电子显微镜、选区电子衍射、紫外-可见光谱和 ζ-电势测量对生物合成的 CrO NPs 进行了表征。通过细胞活力测定和溶血试验评估了 CrO NPs 的生物学特性。得到了粒径约为 25-38nm 的具有特征 Cr-O 振动的纳米粒子，在 417cm处。报告了广谱抗菌潜力和抗氧化性质。观察到对脊髓灰质炎病毒的轻微抑制作用和低剂量的细胞相容性。我们得出结论，生物合成的 CrO NPs 具有多功能性质。
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