Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia; International Postgraduate School Jožef Stefan, Jamova cesta 39, 1000 Ljubljana, Slovenia.
Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Food Chem. 2020 Nov 30;331:127326. doi: 10.1016/j.foodchem.2020.127326. Epub 2020 Jun 18.
A precise and accurate GC-MS/MS method with ng L LLOQs, acceptable recovery (78-107%) and estimated uncertainty (U > 20%, except at LLOQ) was developed following the Eurachem guidelines. We established the migration and stability of twelve bisphenols in two food simulants (C: 20% ethanol, and B: 3% acetic acid) from beverage cans (n = 16) and reusable metal and plastic sports bottles (n = 51). Bisphenols were stable in dried (eight weeks, -20 °C) and derivatised extracts (seven days, 21 °C). Cans leached BPA (<5865 ng L), three BPF isomers (8.2-1286 ng L) and BPAP (1.6 ng L), while bottles leached BPA (<222 ng L) and BPF, BPE, BPB and BPZ (1.1-4.6 ng L). Simulant C was more aggressive than simulant B, and concentrations of bisphenols decreased with consecutive exposure to simulants. Levels of BPA migrating from cans did not exceed the specific migration limits.
建立了一种精确、准确的 GC-MS/MS 方法，LLOQ 低至 ng/L，回收率可接受（78-107%），且估算不确定度（U＞20%，LLOQ 除外），该方法符合 Eurachem 指南。我们研究了 12 种双酚在两种食品模拟物（C：20%乙醇和 B：3%乙酸）中的迁移和稳定性，这些双酚来自饮料罐（n=16）和可重复使用的金属和塑料运动瓶（n=51）。双酚在干燥（-20°C，8 周）和衍生提取物（21°C，7 天）中稳定。罐中溶出的 BPA（<5865ng/L）、三种 BPF 异构体（8.2-1286ng/L）和 BPAP（1.6ng/L），而瓶中溶出的 BPA（<222ng/L）和 BPF、BPE、BPB 和 BPZ（1.1-4.6ng/L）。模拟物 C 比模拟物 B 更具侵蚀性，且双酚浓度随连续暴露于模拟物而降低。从罐中迁移出的 BPA 水平未超过特定迁移限量。
