Laboratoire des Substances Naturelles, Institut National de Recherche et d'Analyse Physico-chimique (INRAP), Biotechpôle de Sidi Thabet, 2020, Tunisia; Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Bizerte, Tunisia.
Laboratoire des Substances Naturelles, Institut National de Recherche et d'Analyse Physico-chimique (INRAP), Biotechpôle de Sidi Thabet, 2020, Tunisia.
Food Chem. 2020 Dec 15;333:127506. doi: 10.1016/j.foodchem.2020.127506. Epub 2020 Jul 10.
Artichoke floral stems (AFS) food waste by-products were examined for their phytochemical constituents and their in vitro and in vivo biological activities. Although that the highest total phenol content and total flavonoid content were found in ethyl acetate extract, methanol extract possessed the strongest DPPH and ABTS radical scavenging activity, and showed the highest reducing ferric antioxidant power (FRAP). The anti-acetylcholinesterase activity was higher in butanol extract, whereas the ethyl acetate extract had the highest inhibitory effect on heat-induced protein denaturation. In alloxan-induced diabetic mice, the AFS methanol extract (AFSE) rich in caffeoylquinic acids and flavones reduced blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, creatinine, and improved liver, and renal antioxidative status. Administration of AFSE to diabetic mice reduced total cholesterol, triglycerides, LDL-cholesterol, and the atherogenic index of plasma (AIP) suggesting its hypolipidemic action. Overall, AFS could be considered as attractive source of health-promoting ingredients.
朝鲜蓟花葶（AFS）食品加工废弃物的植物化学成分及其体外和体内生物活性进行了研究。尽管乙酸乙酯提取物中的总酚含量和总黄酮含量最高，但甲醇提取物具有最强的 DPPH 和 ABTS 自由基清除活性，并表现出最高的还原铁抗氧化能力（FRAP）。丁醇提取物中的乙酰胆碱酯酶抑制活性更高，而乙酸乙酯提取物对热诱导的蛋白质变性具有最强的抑制作用。在链脲佐菌素诱导的糖尿病小鼠中，富含咖啡酰奎宁酸和类黄酮的 AFS 甲醇提取物（AFSE）可降低血糖、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶、肌酐，并改善肝脏和肾脏的抗氧化状态。AFSE 给药可降低糖尿病小鼠的总胆固醇、甘油三酯、LDL-胆固醇和血浆致动脉粥样硬化指数（AIP），表明其具有降血脂作用。总的来说，AFS 可以被认为是一种有吸引力的具有促进健康作用的成分来源。
