The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT- The Arctic University of Norway, 9037, Tromsø, Norway.
Sci Rep. 2020 Jul 20;10(1):11995. doi: 10.1038/s41598-020-68492-3.
Nonulosonic acid (NulO) biosynthesis in bacteria is directed by nab gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of Aliivibrio salmonicida and Moritella viscosa strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method can be used to guide tandem mass spectrometry studies in order to verify the products of previously undescribed nab clusters and identify new members of the NulOs family.
细菌中的非环单羧酸（NulO）生物合成由 nab 基因簇指导，这些基因簇可以导致唾液酸、军团菌酸或 pseudaminic 酸。对主要由鲑鱼气单胞菌和粘膜炎莫拉氏菌菌株组成的一组基因内容的分析揭示了几个独特的 nab 簇的存在，为这些簇预测了 NulO 产物。这种预测方法可用于指导串联质谱研究，以验证以前未描述的 nab 簇的产物并鉴定 NulO 家族的新成员。
