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环状 RNA-UBAP2 通过 miR-382-5p/PRPF8 轴促进卵巢癌细胞的增殖并抑制其凋亡。

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.

机构信息

Department of Reproductive Medicine, Reproductive Medical Centre, The First People's Hospital of Yunnan Province, No. 157 Jin Bi Road, Kunming, People's Republic of China.

Kunming University of Science and Technology, Kunming, People's Republic of China.

出版信息

J Ovarian Res. 2020 Jul 20;13(1):81. doi: 10.1186/s13048-020-00685-w.

DOI:10.1186/s13048-020-00685-w
PMID:32690086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7372761/
Abstract

OBJECTIVE

circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is to explore the role of circRNA-UBAP2 in ovarian cancer and its mechanism.

RESULTS

circRNA-UBAP2 was upregulated in ovarian cancer tissues and cell lines. Knockdown of circRNA-UBAP2 inhibited cell proliferation and promoted cell apoptosis, but circRNA-UBAP2 overexpressed got opposite results. In addition, circRNA-UBAP2 targeted miR-382-5p and downregulated its expression, PRPF8 was a target gene of miR-382-5p. Furthemore, circRNA-UBAP2/miR-382-5p/PRPF8 axis affected the proliferation, apoptosis and cell cycle of ovarian cancer through the mechanism of competing endogenous RNAs (ceRNA).

CONCLUSION

circRNA-UBAP2 acted as a ceRNA to sponged miR-382-5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells.

摘要

目的

环状 RNA（circRNAs）已被报道是多种恶性肿瘤的重要调控因子。然而，circRNAs 在卵巢癌中的功能仍需要进一步探索。本研究旨在探讨 circRNA-UBAP2 在卵巢癌中的作用及其机制。

结果

circRNA-UBAP2 在卵巢癌组织和细胞系中呈上调表达。circRNA-UBAP2 的敲低抑制了细胞增殖并促进了细胞凋亡，而 circRNA-UBAP2 的过表达则得到了相反的结果。此外，circRNA-UBAP2 靶向 miR-382-5p 并下调其表达，PRPF8 是 miR-382-5p 的靶基因。此外，circRNA-UBAP2/miR-382-5p/PRPF8 轴通过竞争性内源性 RNA（ceRNA）机制影响卵巢癌细胞的增殖、凋亡和细胞周期。

结论

circRNA-UBAP2 作为 ceRNA 吸附 miR-382-5p，增加 PRPF8 的表达水平，促进卵巢癌细胞的增殖并抑制其凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/b783bae25d8c/13048_2020_685_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/b05a23b59e4f/13048_2020_685_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/363787a39073/13048_2020_685_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/61c855554324/13048_2020_685_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/77aa98b59b77/13048_2020_685_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/8b43c0503e38/13048_2020_685_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/6d775501d98a/13048_2020_685_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/b783bae25d8c/13048_2020_685_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/b05a23b59e4f/13048_2020_685_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/363787a39073/13048_2020_685_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/61c855554324/13048_2020_685_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/77aa98b59b77/13048_2020_685_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/8b43c0503e38/13048_2020_685_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/6d775501d98a/13048_2020_685_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc9/7372761/b783bae25d8c/13048_2020_685_Fig7_HTML.jpg

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