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儿童HLA - B27相关关节病:长期临床及诊断结果

HLA-B27-associated arthropathy in childhood: long-term clinical and diagnostic outcome.

作者信息

Sheerin K A, Giannini E H, Brewer E J, Barron K S

机构信息

Department of Rheumatology, Texas Children's Hospital, Houston 77225-0269.

出版信息

Arthritis Rheum. 1988 Sep;31(9):1165-70. doi: 10.1002/art.1780310912.

DOI:10.1002/art.1780310912
PMID:3269216
Abstract

We conducted HLA-B27 tissue typing assessments on 430 consecutive children whose main symptom at presentation to our clinic was arthritis/arthralgia. Eighty-five of them (20%) had the B27 antigen. Thirty-six of these children were reexamined after a mean followup period of 8.9 years. Although most had definable rheumatic diseases, only 2 met the New York criteria for ankylosing spondylitis (AS). Children with HLA-B27 and arthritis/arthralgia, although at increased risk of developing AS, have diverse diagnostic and clinical outcomes. The AS criteria used to diagnose the disease in adults may not be appropriate for use in children.

摘要

我们对430名连续就诊的儿童进行了HLA - B27组织分型评估,这些儿童到我们诊所就诊时的主要症状是关节炎/关节痛。其中85名(20%)携带B27抗原。在平均随访8.9年后,对其中36名儿童进行了复查。尽管大多数儿童患有明确的风湿性疾病,但只有2名符合纽约强直性脊柱炎(AS)标准。携带HLA - B27且有关节炎/关节痛的儿童,尽管患AS的风险增加,但诊断和临床结果各不相同。用于诊断成人AS的标准可能不适用于儿童。

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HLA-B27-associated arthropathy in childhood: long-term clinical and diagnostic outcome.儿童HLA - B27相关关节病:长期临床及诊断结果
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