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在 COVID-19 大流行期间死亡率变化模式:基于人群的建模以了解姑息治疗的影响。

Changing patterns of mortality during the COVID-19 pandemic: Population-based modelling to understand palliative care implications.

机构信息

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, UK.

Marie Curie Hospice, Edinburgh, UK.

出版信息

Palliat Med. 2020 Oct;34(9):1193-1201. doi: 10.1177/0269216320944810. Epub 2020 Jul 24.

Abstract

BACKGROUND

COVID-19 has directly and indirectly caused high mortality worldwide.

AIM

To explore patterns of mortality during the COVID-19 pandemic and implications for palliative care, service planning and research.

DESIGN

Descriptive analysis and population-based modelling of routine data.

PARTICIPANTS AND SETTING

All deaths registered in England and Wales between 7 March and 15 May 2020. We described the following mortality categories by age, gender and place of death: (1) baseline deaths (deaths that would typically occur in a given period); (2) COVID-19 deaths and (3) additional deaths not directly attributed to COVID-19. We estimated the proportion of people who died from COVID-19 who might have been in their last year of life in the absence of the pandemic using simple modelling with explicit assumptions.

RESULTS

During the first 10 weeks of the pandemic, there were 101,614 baseline deaths, 41,105 COVID-19 deaths and 14,520 additional deaths. Deaths in care homes increased by 220%, while home and hospital deaths increased by 77% and 90%, respectively. Hospice deaths fell by 20%. Additional deaths were among older people (86% aged ⩾ 75 years), and most occurred in care homes (56%) and at home (43%). We estimate that 22% (13%-31%) of COVID-19 deaths occurred among people who might have been in their last year of life in the absence of the pandemic.

CONCLUSION

The COVID-19 pandemic has led to a surge in palliative care needs. Health and social care systems must ensure availability of palliative care to support people with severe COVID-19, particularly in care homes.

摘要

背景

COVID-19 已在全球范围内直接和间接导致高死亡率。

目的

探索 COVID-19 大流行期间的死亡模式及其对姑息治疗、服务规划和研究的意义。

设计

常规数据的描述性分析和基于人群的建模。

参与者和设置

2020 年 3 月 7 日至 5 月 15 日期间在英格兰和威尔士登记的所有死亡。我们按年龄、性别和死亡地点描述了以下死亡率类别:(1)基线死亡(通常在特定时期发生的死亡);(2)COVID-19 死亡;(3)与 COVID-19 无直接关联的额外死亡。我们使用明确假设的简单模型估计在没有大流行的情况下死于 COVID-19 的人中可能处于生命的最后一年的比例。

结果

在大流行的前 10 周,有 101614 例基线死亡,41105 例 COVID-19 死亡和 14520 例额外死亡。养老院的死亡人数增加了 220%,而家庭和医院的死亡人数分别增加了 77%和 90%。临终关怀的死亡人数下降了 20%。额外死亡发生在老年人中(86%年龄 ⩾ 75 岁),大多数发生在养老院(56%)和家中(43%)。我们估计,22%(13%-31%)的 COVID-19 死亡发生在没有大流行的情况下可能处于生命的最后一年的人群中。

结论

COVID-19 大流行导致姑息治疗需求激增。卫生和社会保健系统必须确保提供姑息治疗,以支持患有严重 COVID-19 的人,特别是在养老院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf55/7495594/e15b5a2910e6/10.1177_0269216320944810-fig1.jpg

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