Department of Human Nutrition, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, Słoneczna 45F, 10-719 Olsztyn, Poland.
Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.
Int J Environ Res Public Health. 2020 Jan 21;17(3):698. doi: 10.3390/ijerph17030698.
Colorectal cancer (CRC) is one of the most common and lethal types of cancer worldwide. The developing of this disease includes many factors such as genetic, socioeconomic, environmental, and lifestyle factors, and nutrition habits. The aim of the study is the determination of zearalenone and its metabolite level in the biological samples of participants at risk of CRC, in relation to the nutrition data and information on the quality of life dependent on health. In the cohort clinical trial, 150 participants aged between 50 and 65 will be studied. The participants will be assigned into two groups depending on the colonoscopy result. Participants will be tested at dietary intake, quality of life, sleep time and quality, stress level as well as biochemical parameters of the blood. Moreover, in the biological samples, concentration of zearalenone and its metabolites (α-zearalenol and β-zearalenol) as well as the characteristics of gastrointestinal bacterial will be determined, and the end of the trial for both groups and their results will be compared. Taking into account the possible effect of mycotoxins and nutrition habits on the development of cancer, the results obtained may allow the formulation of new nutritional recommendations and reduce the development and occurrence of CRC.
结直肠癌（CRC）是全球最常见和最致命的癌症类型之一。这种疾病的发展包括许多因素，如遗传、社会经济、环境和生活方式因素，以及营养习惯。本研究的目的是确定处于 CRC 风险中的参与者的生物样本中的玉米赤霉烯酮及其代谢物水平，以及与营养数据和健康相关的生活质量信息。在队列临床试验中，将研究 150 名年龄在 50 至 65 岁之间的参与者。根据结肠镜检查结果，将参与者分为两组。将对参与者的饮食摄入、生活质量、睡眠时间和质量、压力水平以及血液的生化参数进行测试。此外，还将在生物样本中测定玉米赤霉烯酮及其代谢物（α-玉米赤霉烯醇和β-玉米赤霉烯醇）的浓度以及胃肠道细菌的特征，并对两组的试验结束及其结果进行比较。考虑到霉菌毒素和营养习惯对癌症发展的可能影响，获得的结果可能允许制定新的营养建议，并减少 CRC 的发展和发生。
